Impact of COVID-19 infection on lung function and nutritional status amongst individuals with cystic fibrosis: A global cohort study

Semenchuk J, Naito Y, Charman SC, Carr SB, Cheng SY, Marshall BC, Faro A, Elbert A, Gutierrez HH, Goss CH, Karadag B, Burgel PR, Colombo C, Salvatore M, Padoan R, Daneau G, Harutyunyan S, Kashirskaya N, Kirwan L, Middleton PG, Ruseckaite R, de Monestrol I, Naehrlich L, Mondejar-Lopez P, Jung A, van Rens J, Bakkeheim E, Orenti A, Zomer-van Ommen D, da Silva-Filho LVR, Fernandes FF, Zampoli M, Stephenson AL, Kasmi I, Drali O, Burghart S, Lakatos-Krepcik A, Eder J, Jaksch P, Kainz K, Kallinger M, Leitner A, Mozdzen M, Pfleger A, Renner S, Stadlinger M, Thir C, Nuriyev E, Boboli H, De Wachter E, Dupont L, Gohy S, Hanssens L, Knoop C, Lammertyn E, Nowé V, Pirson J, Thimmesch M, Van Braeckel E, Van Hoorenbeeck K, Vanderhelst E, Filho EP, Athanazio RA, Martins VdC, Duarte MC, Monte LdFV, de Fuccio MB, Knabben AdSC, Melloti R, Meneses DG, Petrova G, Tješić-Drinković D, Dugac AV, Bambir I, Yiallouros P, Bilkova A, Drevinek P, Macek M, Olesen HV, Pressler T, Fouda EM, Nasr S, Weldetsadik AY, Al-iede M, Abdrakhmanov O, Corvol H, Lemonnier-Videau L, Abely M, Piccini CB, Belleguic C, Bihouee T, Billon Y, Bui S, Camara B, Cheraud MC, Chiron R, Duet EC, Cosson L, Dalphin ML, Boucher ID, De Miranda S, Deneuville E, Dubus JC, Durieu I, Epaud R, Gerardin M, Grenet D, Houdouin V, Huet F, Reem K, Kessler R, Languepin J, Laurans M, Leroy S, Llerena C, Macey J, Mankikian J, Marguet C, Martin C, Mely L, Mittaine M, Murris-Espin M, Perisson C, Prevotat A, Ramel S, Rames C, Reix P, Revillon M, Reynaud-Gaubert M, Richaud-Thiriez B, Rittie JL, Scalbert-Dujardin M, Sermet-Gaudelus I, Storni V, Tatopoulos A, Thouvenin G, Troussier F, Weiss L, Wizla N, Behl ES, Brinkmann F, Claßen M, Graepler-Mainka U, Griese M, Grübl A, Hammermann J, Hebestreit H, Heinzmann A, Herz A, Kiefer A, Kinder B, Köster H, Kuhnert S, Mainz J, Mayer A, Naehrig S, Niehues T, Nüßlein T, Poplawska K, Ringshausen F, Rose M, Rosenecker J, Ruppel R, Scharschinger A, Schropp C, Schwarz C, Smaczny C, Sommerburg O, Sutharsan S, Stolz S, Thomas W, Wege S, Welzenbach B, Wollschläger B, Diamantea F, Hatziagorou E, Manika K, Cox D, Elnazir B, Fletcher G, Gunaratnam C, McKone EF, Plant BJ, Cohen-Cymberknoh M, Gur M, Livnat G, Mei-Zahav M, Amato A, Ferrari G, Badolato R, Poli P, Battistini F, Donati V, Bignamini E, Folino A, Carnovale V, Castellani C, Casciaro R, Cimino G, Cipolli M, Lucca F, Collura M, Ficili F, Daccò V, Gagliano V, Pizzamiglio G, Mencarini V, Palladino N, Leonardi S, Rotolo N, Lucanto MC, Quattromano E, Lucidi V, Majo F, Alghisi F, Ciciriello F, Manca A, Leonetti G, Maschio M, Messore B, Pantano S, Pisi G, Spaggiari C, Raia V, Laezza C, Ros M, Salvatore D, Taccetti G, Francalanci M, Vitullo P, Zolin A, Aleksejeva E, Malakauskas K, Misevičiene V, Charatsi AM, la Barrière HD, Altenburg J, Bannier M, Heijerman H, Janssens H, Koppelman G, van der Meer R, Merkus P, Nuijsink M, Terheggen S, van der Vaart H, Wesseling GJ, de Winter K, Danevska IA, Maretti TJ, Fustik S, Dziecichowicz-Latała D, Wojsyk-Banaszak I, Wozniacki L, Amorim A, Santos ASA, Castanhinha S, Gamboa F, Silva TR, Gonçalves F, Pereira L, Ciuca I, Silva S, Csilla-Enikö S, Stan I, Amelina E, Boitсova E, Chernyavskaya A, Gorinova Y, Krasovskiy S, Mukhina M, Sherman V, Simonova O, Kondratyeva E, Bérešová E, Bližnáková N, Kayserová H, Salobir B, Šelb J, Krivec U, Fernandez AJA, Fernàndez AA, García FB, Aparicio MB, Corullón SC, Cortell-Aznar I, Pérez I, Colomer JCi, Roig MC, Pecellín ID, Cáceres LD, Paredes CL, Gartner S, Martínez JRG, Labarga IH, Girón-Moreno RM, Nogueira EJ, Ferreiro AL, Neyra AL, Castro EB, Galarraga LM, de Vincente CM, Navarro SM, Nieto-Royo R, Fuster CO, Pastor MD, Pérez-Ruiz E, Prados-Sánchez C, Cancelo IR, de Valbuena MR, Asensi JR, Santiago VS, García PF, Tawfeeq RM, Banki A, Gilljam M, Krantz C, Lindberg U, Lindblad A, Clarenbach C, Steinack C, Hage R, Schuurmans M, Fischer R, Kusche R, Rochat I, Walter AL, Kamalaporn H, Hamouda S, Tural DA, Ozcelik U, Asfuroğlu P, Eyüboğlu TŞ, Aslan AT, Bingöl A, Çobanoğlu N, Ozcan G, Dogru D, Gökdemir Y, KÖSE M, Pekcan S, Cosgriff R (2024)


Publication Type: Journal article

Publication year: 2024

Journal

Book Volume: 23

Pages Range: 815-822

Journal Issue: 5

DOI: 10.1016/j.jcf.2024.07.019

Abstract

Background: Factors associated with severe COVID-19 infection have been identified; however, the impact of infection on longer-term outcomes is unclear. The objective of this study was to examine the impact of COVID-19 infection on the trajectory of lung function and nutritional status in people with cystic fibrosis (pwCF). Methods: This is a retrospective global cohort study of pwCF who had confirmed COVID-19 infection diagnosed between January 1, 2020 and December 31, 2021. Forced expiratory volume in one second percent predicted (ppFEV1) and body mass index (BMI) twelve months prior to and following a diagnosis of COVID-19 were recorded. Change in mean ppFEV1 and BMI were compared using a t-test. A linear mixed-effects model was used to estimate change over time and to compare the rate of change before and after infection. Results: A total of 6,500 cases of COVID-19 in pwCF from 33 countries were included for analysis. The mean difference in ppFEV1 pre- and post-infection was 1.4 %, (95 % CI 1.1, 1.7). In those not on modulators, the difference in rate of change pre- and post-infection was 1.34 %, (95 % CI -0.88, 3.56) per year (p = 0.24) and -0.74 % (-1.89, 0.41) per year (p = 0.21) for those on elexacaftor/tezacaftor/ivacaftor. No clinically significant change was noted in BMI or BMI percentile before and after COVID-19 infection. Conclusions: No clinically meaningful impact on lung function and BMI trajectory in the year following infection with COVID-19 was identified. This work highlights the ability of the global CF community to unify and address critical issues facing pwCF.

How to cite

APA:

Semenchuk, J., Naito, Y., Charman, S.C., Carr, S.B., Cheng, S.Y., Marshall, B.C.,... Cosgriff, R. (2024). Impact of COVID-19 infection on lung function and nutritional status amongst individuals with cystic fibrosis: A global cohort study. Journal of Cystic Fibrosis, 23(5), 815-822. https://doi.org/10.1016/j.jcf.2024.07.019

MLA:

Semenchuk, Julie, et al. "Impact of COVID-19 infection on lung function and nutritional status amongst individuals with cystic fibrosis: A global cohort study." Journal of Cystic Fibrosis 23.5 (2024): 815-822.

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