Simultaneous whole-liver water T1 and T2 mapping with isotropic resolution during free-breathing
Stelter J, Weiss K, Steinhelfer L, Spieker V, Huaroc Moquillaza E, Zhang W, Makowski MR, Schnabel JA, Kainz B, Braren RF, Karampinos DC (2024)
Publication Type: Journal article
Publication year: 2024
Journal
DOI: 10.1002/nbm.5216
Abstract
Purpose: To develop and validate a data acquisition scheme combined with a motion-resolved reconstruction and dictionary-matching-based parameter estimation to enable free-breathing isotropic resolution self-navigated whole-liver simultaneous water-specific (Formula presented.) ((Formula presented.)) and (Formula presented.) ((Formula presented.)) mapping for the characterization of diffuse and oncological liver diseases. Methods: The proposed data acquisition consists of a magnetization preparation pulse and a two-echo gradient echo readout with a radial stack-of-stars trajectory, repeated with different preparations to achieve different (Formula presented.) and (Formula presented.) contrasts in a fixed acquisition time of 6 min. Regularized reconstruction was performed using self-navigation to account for motion during the free-breathing acquisition, followed by water–fat separation. Bloch simulations of the sequence were applied to optimize the sequence timing for (Formula presented.) insensitivity at 3 T, to correct for relaxation-induced blurring, and to map (Formula presented.) and (Formula presented.) using a dictionary. The proposed method was validated on a water–fat phantom with varying relaxation properties and in 10 volunteers against imaging and spectroscopy reference values. The performance and robustness of the proposed method were evaluated in five patients with abdominal pathologies. Results: Simulations demonstrate good (Formula presented.) insensitivity of the proposed method in measuring (Formula presented.) and (Formula presented.) values. The proposed method produces co-registered (Formula presented.) and (Formula presented.) maps with a good agreement with reference methods (phantom: (Formula presented.); (Formula presented.)). The proposed (Formula presented.) and (Formula presented.) mapping exhibits good repeatability and can be robustly performed in patients with pathologies. Conclusions: The proposed method allows whole-liver (Formula presented.) and (Formula presented.) quantification with high accuracy at isotropic resolution in a fixed acquisition time during free-breathing.
Authors with CRIS profile
Involved external institutions
Koninklijke Philips N.V.
Netherlands (NL)
Technische Universität München (TUM)
Germany (DE)
Institute of Machine Learning for Biomedical Imaging
Germany (DE)
Imperial College London / The Imperial College of Science, Technology and Medicine
United Kingdom (GB)
Netherlands (NL)
Technische Universität München (TUM)
Germany (DE)
Institute of Machine Learning for Biomedical Imaging
Germany (DE)
Imperial College London / The Imperial College of Science, Technology and Medicine
United Kingdom (GB)
How to cite
APA:
Stelter, J., Weiss, K., Steinhelfer, L., Spieker, V., Huaroc Moquillaza, E., Zhang, W.,... Karampinos, D.C. (2024). Simultaneous whole-liver water T1 and T2 mapping with isotropic resolution during free-breathing. NMR in Biomedicine. https://doi.org/10.1002/nbm.5216
MLA:
Stelter, Jonathan, et al. "Simultaneous whole-liver water T1 and T2 mapping with isotropic resolution during free-breathing." NMR in Biomedicine (2024).
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