New Insights Into Application Relevant Properties of Cu2+-Doped Brushite Cements

Späth K, Nawaz Q, Schilling T, Götz-Neunhoeffer F, Detsch R, Boccaccini AR, Hurle K (2024)

Publication Type: Journal article

Publication year: 2024

Journal

Journal of Biomedical Materials Research Part B: Applied Biomaterials Wiley

Book Volume: 112

Article Number: e35479

Journal Issue: 9

DOI: 10.1002/jbm.b.35479

Abstract

Doping of brushite cements with metal ions can entail many positive effects on biological and physicochemical properties. Cu2+ ions are known to exhibit antibacterial properties and can additionally have different positive effects on cells as trace elements, whereas high Cu2+ concentrations are cytotoxic. For therapeutical applications of bone cement, a combination of good biocompatibility and sufficient mechanical properties is required. Therefore, the aim of this study was to investigate different physicochemical and biological aspects, relevant for application, of a brushite cement with Cu2+-doped β-tricalcium phosphate, monocalcium phosphate monohydrate and phytic acid as setting retarder. Additionally, the ion release was compared with a cement with citric acid as setting retarder. The investigated cements showed good injectability coefficients, as well as compressive strength values sufficient for application. Furthermore, no antibacterial effects were detected irrespective of the Cu2+ concentration or the bacterial strain. The cell experiments with eluate samples showed that the viability of MC3T3-E1 cells tended to decrease with increasing Cu2+ concentration in the cement. It is suggested that these biological responses are caused by the difference in the Cu2+ release from the hardened cement depending on the solvent medium. Furthermore, the cements showed a steady release of Cu2+ ions to a lesser extent in comparison with a cement with citric acid as setting retarder, where a burst release of Cu2+ was observed. In conclusion, despite the anticipated antibacterial effect of Cu2+-doped cements was lacking and mammalian cell viability was slightly affected, Cu2+-concentrations maintained the physicochemical properties as well as the compressive strength of cements and the slow ion release from cements produced with phytic acid is considered advantageous compared to citric acid-based formulations.

Authors with CRIS profile

Karla Späth Lehrstuhl für Mineralogie Qaisar Nawaz Lehrstuhl für Feststoff- und Grenzflächenverfahrenstechnik Friedlinde Götz-Neunhoeffer Naturwissenschaftliche Fakultät Rainer Detsch Lehrstuhl für Werkstoffwissenschaften (Biomaterialien) Aldo Boccaccini Lehrstuhl für Werkstoffwissenschaften (Biomaterialien) Katrin Hurle Lehrstuhl für Mineralogie

Additional Organisation(s)

FAU Forschungszentrum Neue Wirkstoffe (FAU NeW)

Involved external institutions

Julius-Maximilians-Universität Würzburg DE Germany (DE)

How to cite

APA:

Späth, K., Nawaz, Q., Schilling, T., Götz-Neunhoeffer, F., Detsch, R., Boccaccini, A.R., & Hurle, K. (2024). New Insights Into Application Relevant Properties of Cu2+-Doped Brushite Cements. Journal of Biomedical Materials Research Part B: Applied Biomaterials, 112(9). https://doi.org/10.1002/jbm.b.35479

MLA:

Späth, Karla, et al. "New Insights Into Application Relevant Properties of Cu2+-Doped Brushite Cements." Journal of Biomedical Materials Research Part B: Applied Biomaterials 112.9 (2024).

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