Lymphoid tissue fibrosis is associated with impaired vaccine responses

Kityo C, Makamdop KN, Rothenberger M, Chipman JG, Hoskuldsson T, Beilman GJ, Grzywacz B, Mugyenyi P, Ssali F, Akondy RS, Anderson J, Schmidt TE, Reimann T, Callisto SP, Schoephoerster J, Schuster J, Muloma P, Ssengendo P, Moysi E, Petrovas C, Lanciotti R, Zhang L, Arévalo MT, Rodriguez B, Ross TM, Trautmann L, Sekaly RP, Lederman MM, Koup RA, Ahmed R, Reilly C, Douek DC, Schacker TW (2018)

Publication Type: Journal article

Publication year: 2018

Journal

Journal of Clinical Investigation American Society for Clinical Investigation

Book Volume: 128

Pages Range: 2763-2773

Journal Issue: 7

DOI: 10.1172/JCI97377

Abstract

Vaccine responses vary by geographic location. We have previously described how HIV-associated inflammation leads to fibrosis of secondary lymph nodes (LNs) and T cell depletion. We hypothesized that other infections may cause LN inflammation and fibrosis, in a process similar to that seen in HIV infection, which may lead to T cell depletion and affect vaccine responses. We studied LNs of individuals from Kampala, Uganda, before and after yellow fever vaccination (YFV) and found fibrosis in LNs that was similar to that seen in HIV infection. We found blunted antibody responses to YFV that correlated to the amount of LN fibrosis and loss of T cells, including T follicular helper cells. These data suggest that LN fibrosis is not limited to HIV infection and may be associated with impaired immunologic responses to vaccines. This may have an impact on vaccine development, especially for infectious diseases prevalent in the developing world.

Involved external institutions

Joint Clinical Research Centre UG Uganda (UG) National Institute of Allergy and Infectious Diseases US United States (USA) (US) University of Minnesota (UMN) US United States (USA) (US) University of Georgia (UGA) US United States (USA) (US) Case Western Reserve University US United States (USA) (US) Walter Reed Army Institute of Research (WRAIR) US United States (USA) (US) Emory University US United States (USA) (US) Centers for Disease Control and Prevention US United States (USA) (US)

How to cite

APA:

Kityo, C., Makamdop, K.N., Rothenberger, M., Chipman, J.G., Hoskuldsson, T., Beilman, G.J.,... Schacker, T.W. (2018). Lymphoid tissue fibrosis is associated with impaired vaccine responses. Journal of Clinical Investigation, 128(7), 2763-2773. https://doi.org/10.1172/JCI97377

MLA:

Kityo, Cissy, et al. "Lymphoid tissue fibrosis is associated with impaired vaccine responses." Journal of Clinical Investigation 128.7 (2018): 2763-2773.

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