Physical Principles of Membrane Shape Regulation by the Glycocalyx
Shurer CR, Kuo JCH, Roberts LDM, Gandhi JG, Colville MJ, Enoki TA, Pan H, Su J, Noble JM, Hollander MJ, O'Donnell JP, Yin R, Pedram K, Möckl L, Kourkoutis LF, Moerner WE, Bertozzi CR, Feigenson GW, Reesink HL, Paszek MJ (2019)
Publication Type: Journal article
Publication year: 2019
Journal
Book Volume: 177
Pages Range: 1757-1770.e21
Journal Issue: 7
DOI: 10.1016/j.cell.2019.04.017
Abstract
Cells bend their plasma membranes into highly curved forms to interact with the local environment, but how shape generation is regulated is not fully resolved. Here, we report a synergy between shape-generating processes in the cell interior and the external organization and composition of the cell-surface glycocalyx. Mucin biopolymers and long-chain polysaccharides within the glycocalyx can generate entropic forces that favor or disfavor the projection of spherical and finger-like extensions from the cell surface. A polymer brush model of the glycocalyx successfully predicts the effects of polymer size and cell-surface density on membrane morphologies. Specific glycocalyx compositions can also induce plasma membrane instabilities to generate more exotic undulating and pearled membrane structures and drive secretion of extracellular vesicles. Together, our results suggest a fundamental role for the glycocalyx in regulating curved membrane features that serve in communication between cells and with the extracellular matrix.
Involved external institutions
United States (USA) (US)How to cite
APA:
Shurer, C.R., Kuo, J.C.H., Roberts, L.D.M., Gandhi, J.G., Colville, M.J., Enoki, T.A.,... Paszek, M.J. (2019). Physical Principles of Membrane Shape Regulation by the Glycocalyx. Cell, 177(7), 1757-1770.e21. https://doi.org/10.1016/j.cell.2019.04.017
MLA:
Shurer, Carolyn R., et al. "Physical Principles of Membrane Shape Regulation by the Glycocalyx." Cell 177.7 (2019): 1757-1770.e21.
BibTeX: Download