Small molecule inhibitors of mammalian glycosylation
Almahayni K, Spiekermann M, Fiore A, Yu G, Pedram K, Möckl L (2022)
Publication Type: Journal article
Publication year: 2022
Journal
Book Volume: 16
Article Number: 100108
DOI: 10.1016/j.mbplus.2022.100108
Abstract
Glycans are one of the fundamental biopolymers encountered in living systems. Compared to polynucleotide and polypeptide biosynthesis, polysaccharide biosynthesis is a uniquely combinatorial process to which interdependent enzymes with seemingly broad specificities contribute. The resulting intracellular cell surface, and secreted glycans play key roles in health and disease, from embryogenesis to cancer progression. The study and modulation of glycans in cell and organismal biology is aided by small molecule inhibitors of the enzymes involved in glycan biosynthesis. In this review, we survey the arsenal of currently available inhibitors, focusing on agents which have been independently validated in diverse systems. We highlight the utility of these inhibitors and drawbacks to their use, emphasizing the need for innovation for basic research as well as for therapeutic applications.
Involved external institutions
Max-Planck-Institut für die Physik des Lichts (MPL) / Max Planck Institute for the Science of Light
Germany (DE)
Janelia Research Campus
United States (USA) (US)
Germany (DE)
Janelia Research Campus
United States (USA) (US)
How to cite
APA:
Almahayni, K., Spiekermann, M., Fiore, A., Yu, G., Pedram, K., & Möckl, L. (2022). Small molecule inhibitors of mammalian glycosylation. Matrix Biology Plus, 16. https://doi.org/10.1016/j.mbplus.2022.100108
MLA:
Almahayni, Karim, et al. "Small molecule inhibitors of mammalian glycosylation." Matrix Biology Plus 16 (2022).
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