Eosinophil extracellular vesicles and DNA traps in allergic inflammation
Weihrauch T, Melo RC, Gray N, Vöhringer D, Weller PF, Raap U (2024)
Publication Type: Journal article
Publication year: 2024
Journal
Book Volume: 5
Article Number: 1448007
DOI: 10.3389/falgy.2024.1448007
Abstract
Eosinophil granulocytes, a specialized subset of white blood cells, have traditionally been associated with allergic responses and parasitic infections. However, recent research has unveiled their versatile roles in immune regulation beyond these classical functions. This review highlights the emerging field of eosinophil biology, with a particular focus on their release of extracellular vesicles (EVs) and extracellular DNA traps (EETs). It further explores potential implications of eosinophil-derived EVs and EETs for immune responses during inflammatory diseases. The release of EVs/EETs from eosinophils, which also affects the eosinophils themselves, may influence both local and systemic immune reactions, affecting the pathophysiology of conditions such as airway inflammation, chronic rhinosinusitis and atopic dermatitis.
Authors with CRIS profile
Involved external institutions
Carl von Ossietzky Universität Oldenburg
Germany (DE)
Universidade Federal de Juiz de Fora (UFJF)
Brazil (BR)
Veterans Affairs Healthcare System Boston and Harvard Medical School
United States (USA) (US)
Germany (DE)
Universidade Federal de Juiz de Fora (UFJF)
Brazil (BR)
Veterans Affairs Healthcare System Boston and Harvard Medical School
United States (USA) (US)
How to cite
APA:
Weihrauch, T., Melo, R.C., Gray, N., Vöhringer, D., Weller, P.F., & Raap, U. (2024). Eosinophil extracellular vesicles and DNA traps in allergic inflammation. Frontiers in Allergy, 5. https://doi.org/10.3389/falgy.2024.1448007
MLA:
Weihrauch, Tobias, et al. "Eosinophil extracellular vesicles and DNA traps in allergic inflammation." Frontiers in Allergy 5 (2024).
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