Seufert C, Borutta M, Regensburger M, Zhao Y, Kinfe TM (2024)
Publication Type: Journal article, Review article
Publication year: 2024
Book Volume: 12
Article Number: 1824
Journal Issue: 8
DOI: 10.3390/biomedicines12081824
Parkinson’s Disease is a neurodegenerative disorder manifesting itself as a hypokinetic movement impairment with postural instability and gait disturbance. In case of failure and/or limited response, deep brain stimulation has been established as an alternative and effective treatment modality. However, a subset of PD patients with gait impairment represents a therapeutic challenge. A systematic review (2000–2023) was performed using PubMed, Embase, Web of Science, Scopus, and Cochrane Library databases to determine the efficacy, stimulation waveform/parameters, spine level, and outcome measures of spinal cord stimulation using different waveforms in PD patients with and without chronic pain. Spinal cord stimulation responsiveness was assessed within the pre-defined follow-up period in three groups (short-term follow-up = 0–3 months; intermediate follow-up = 3–12 months; and long-term follow-up = more than 12 months). In addition, we briefly outline alternative neurostimulation therapies and the most recent developments in closed-loop spinal cord stimulation relevant to PD. In summary, 18 publications and 70 patients from uncontrolled observational trials were included, with low-quality evidence and conflicting findings. First and foremost, the currently available data do not support the use of spinal cord stimulation to treat PD-related gait disorders but have confirmed its usefulness for PD-associated chronic pain.
APA:
Seufert, C., Borutta, M., Regensburger, M., Zhao, Y., & Kinfe, T.M. (2024). New Perspectives for Spinal Cord Stimulation in Parkinson’s Disease-Associated Gait Impairment: A Systematic Review. Biomedicines, 12(8). https://doi.org/10.3390/biomedicines12081824
MLA:
Seufert, Christian, et al. "New Perspectives for Spinal Cord Stimulation in Parkinson’s Disease-Associated Gait Impairment: A Systematic Review." Biomedicines 12.8 (2024).
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