Donor-Derived Cell-Free DNA as a Companion Biomarker for AMR Treatment With Daratumumab: Case Series

Osmanodja B, Akifova A, Budde K, Oellerich M, Beck J, Bornemann-Kolatzki K, Schütz E, Velden J, Lehmann C, Krüger BM, Bachmann A, Kowald J (2024)

Publication Type: Journal article

Publication year: 2024

Journal

Transplant International Wiley-Blackwell

Book Volume: 37

Article Number: 13213

DOI: 10.3389/ti.2024.13213

Abstract

Antibody-mediated rejection (AMR) is among the most frequent causes for graft loss after kidney transplantation. While there are no approved therapies, several case reports with daratumumab and the very recent phase 2 trial of felzartamab in AMR have indicated the potential efficacy of therapeutic interventions targeting CD38. Donor-derived cell-free DNA (dd-cfDNA) is an emerging biomarker with injury-specific release and a short half-life, which could facilitate early diagnosis of AMR and monitoring of treatment response. We describe two cases of patients with chronic active AMR, who were treated with monthly daratumumab infusions, and in whom donor-derived cell-free DNA (dd-cfDNA) was measured longitudinally to monitor treatment response. In both patients, daratumumab treatment led to stabilization of kidney function parameters, a strong decline of dd-cfDNA below the previously established threshold for rejection, and partial or complete histologic resolution of AMR activity. Our case series suggests that dd-cfDNA may be a useful companion biomarker for longitudinal monitoring of anti-CD38 treatment in patients with AMR.

Authors with CRIS profile

Joachim Velden Department of Nephropathology

Involved external institutions

Universitätsklinikum Leipzig DE Germany (DE) Universität Leipzig DE Germany (DE) Berliner Institut für Gesundheitsforschung (BIH) DE Germany (DE) Universitätsklinikum Göttingen DE Germany (DE) Chronix Biomedical GmbH DE Germany (DE)

How to cite

APA:

Osmanodja, B., Akifova, A., Budde, K., Oellerich, M., Beck, J., Bornemann-Kolatzki, K.,... Kowald, J. (2024). Donor-Derived Cell-Free DNA as a Companion Biomarker for AMR Treatment With Daratumumab: Case Series. Transplant International, 37. https://doi.org/10.3389/ti.2024.13213

MLA:

Osmanodja, Bilgin, et al. "Donor-Derived Cell-Free DNA as a Companion Biomarker for AMR Treatment With Daratumumab: Case Series." Transplant International 37 (2024).

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