Pronounced neonatal breast enlargement beyond the first week of life and its regression correlates with serum prolactin levels – a case series

Bartos HB, Weise L, Schock A, Diez S, Weiss C, Drommelschmidt K, Mahnken AH, Hummler H, Müller H (2024)

Publication Type: Journal article

Publication year: 2024

Journal

Journal of Pediatric Endocrinology & Metabolism Freund Publishing House / Walter de Gruyter

DOI: 10.1515/jpem-2024-0230

Abstract

Objectives: Mild breast swelling is frequently observed in newborns during the first postnatal week. Breast enlargement is also observed in a minor proportion of infants beyond the first postnatal week, leading to discussions how to deal with it. Our objective was to review a case series of infants with prolonged breast swelling. Case presentation: We examined five infants with pronounced breast enlargement beyond the first postnatal week and measured human chorionic gonadotropin (HCG), estradiol (E2), follicle-stimulating hormone (FSH), luteinizing hormone (LH), prolactin (PRL), and progesterone (P4) in blood samples and analyzed breast volume by sonographic volume determination in all infants initially and across time. The regression of breast enlargement positively correlated with serum prolactin levels in infants with breast enlargement beyond the first week of life. Complete regression occurred after several weeks and was characterized by normalization of serum prolactin levels. Conclusions: The present study emphasizes the role of prolactin in neonates with pronounced breast enlargement beyond the first week of life.

Authors with CRIS profile

Sonja Diez Department of Paediatric Surgery

Involved external institutions

Universitätsklinikum Gießen und Marburg (UKGM) DE Germany (DE) Universitätsklinikum Mannheim DE Germany (DE) Universitätsklinikum Essen DE Germany (DE)

How to cite

APA:

Bartos, H.B., Weise, L., Schock, A., Diez, S., Weiss, C., Drommelschmidt, K.,... Müller, H. (2024). Pronounced neonatal breast enlargement beyond the first week of life and its regression correlates with serum prolactin levels – a case series. Journal of Pediatric Endocrinology & Metabolism. https://doi.org/10.1515/jpem-2024-0230

MLA:

Bartos, Hilda Brigitta, et al. "Pronounced neonatal breast enlargement beyond the first week of life and its regression correlates with serum prolactin levels – a case series." Journal of Pediatric Endocrinology & Metabolism (2024).

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