Bone morphogenetic protein 2 signaling negatively modulates lymphatic development in vertebrate embryos
Dunworth WP, Cardona-Costa J, Bozkulak EC, Kim JD, Meadows S, Fischer JC, Wang Y, Cleaver O, Qyang Y, Ober EA, Jin SW (2014)
Publication Type: Journal article
Publication year: 2014
Journal
Book Volume: 114
Pages Range: 56-66
Journal Issue: 1
DOI: 10.1161/CIRCRESAHA.114.302452
Abstract
Rationale: The emergence of lymphatic endothelial cells (LECs) seems to be highly regulated during development. Although several factors that promote the differentiation of LECs in embryonic development have been identified, those that negatively regulate this process are largely unknown. Objective: Our aim was to delineate the role of bone morphogenetic protein (BMP) 2 signaling in lymphatic development. Methods and results: BMP2 signaling negatively regulates the formation of LECs. Developing LECs lack any detectable BMP signaling activity in both zebrafish and mouse embryos, and excess BMP2 signaling in zebrafish embryos and mouse embryonic stem cell-derived embryoid bodies substantially decrease the emergence of LECs. Mechanistically, BMP2 signaling induces expression of miR-31 and miR-181a in a SMAD-dependent mechanism, which in turn results in attenuated expression of prospero homeobox protein 1 during development. Conclusions: Our data identify BMP2 as a key negative regulator for the emergence of the lymphatic lineage during vertebrate development. © 2013 American Heart Association, Inc.
Involved external institutions
National Institute for Medical Research
United Kingdom (GB)
Yale School of Medicine
United States (USA) (US)
University of Texas Southwestern Medical Center (UT Southwestern)
United States (USA) (US)
United Kingdom (GB)
Yale School of Medicine
United States (USA) (US)
University of Texas Southwestern Medical Center (UT Southwestern)
United States (USA) (US)
How to cite
APA:
Dunworth, W.P., Cardona-Costa, J., Bozkulak, E.C., Kim, J.D., Meadows, S., Fischer, J.C.,... Jin, S.W. (2014). Bone morphogenetic protein 2 signaling negatively modulates lymphatic development in vertebrate embryos. Circulation Research, 114(1), 56-66. https://doi.org/10.1161/CIRCRESAHA.114.302452
MLA:
Dunworth, William P., et al. "Bone morphogenetic protein 2 signaling negatively modulates lymphatic development in vertebrate embryos." Circulation Research 114.1 (2014): 56-66.
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