At new heights – Endodermal lineages in development and disease

Ober EA, Grapin-Botton A (2015)


Publication Type: Journal article

Publication year: 2015

Journal

Book Volume: 142

Pages Range: 1912-1917

Journal Issue: 11

DOI: 10.1242/dev.121095

Abstract

The endoderm gives rise to diverse tissues and organs that are essential for the homeostasis and metabolism of the organism: the thymus, thyroid, lungs, liver and pancreas, and the functionally diverse domains of the digestive tract. Classically, the endoderm, the ‘innermost germ layer’, was in the shadow of the ectoderm and mesoderm. However, at a recent Keystone meeting it took center stage, revealing astonishing progress in dissecting the mechanisms underlying the development and malfunction of the endodermal organs. In vitro cultures of stem and progenitor cells have become widespread, with remarkable success in differentiating three-dimensional organoids, which – in a new turn for the field – can be used as disease models.

Authors with CRIS profile

Involved external institutions

How to cite

APA:

Ober, E.A., & Grapin-Botton, A. (2015). At new heights – Endodermal lineages in development and disease. Development, 142(11), 1912-1917. https://doi.org/10.1242/dev.121095

MLA:

Ober, Elke A., and Anne Grapin-Botton. "At new heights – Endodermal lineages in development and disease." Development 142.11 (2015): 1912-1917.

BibTeX: Download