Vegfc Regulates Bipotential Precursor Division and Prox1 Expression to Promote Lymphatic Identity in Zebrafish

Koltowska K, Lagendijk AK, Pichol-Thievend C, Fischer JC, Francois M, Ober EA, Yap AS, Hogan BM (2015)

Publication Type: Journal article

Publication year: 2015

Journal

Cell Reports Elsevier (Cell Press)

Book Volume: 13

Pages Range: 1828-1841

Journal Issue: 9

DOI: 10.1016/j.celrep.2015.10.055

Abstract

Lymphatic vessels arise chiefly from preexisting embryonic veins. Genetic regulators of lymphatic fate are known, but how dynamic cellular changes contribute during the acquisition of lymphatic identity is not understood. We report the visualization of zebrafish lymphatic precursor cell dynamics during fate restriction. In the cardinal vein, cellular commitment is linked with the division of bipotential Prox1-positive precursor cells, which occurs immediately prior to sprouting angiogenesis. Following precursor division, identities are established asymmetrically in daughter cells; one daughter cell becomes lymphatic and progressively upregulates Prox1, and the other downregulates Prox1 and remains in the vein. Vegfc drives cell division and Prox1 expression in lymphatic daughter cells, coupling signaling dynamics with daughter cell fate restriction and precursor division.

Involved external institutions

University of Queensland AU Australia (AU) Novo Nordisk Foundation / Novo Nordisk Fonden (NNF) DK Denmark (DK) National Institute for Medical Research GB United Kingdom (GB)

How to cite

APA:

Koltowska, K., Lagendijk, A.K., Pichol-Thievend, C., Fischer, J.C., Francois, M., Ober, E.A.,... Hogan, B.M. (2015). Vegfc Regulates Bipotential Precursor Division and Prox1 Expression to Promote Lymphatic Identity in Zebrafish. Cell Reports, 13(9), 1828-1841. https://doi.org/10.1016/j.celrep.2015.10.055

MLA:

Koltowska, Katarzyna, et al. "Vegfc Regulates Bipotential Precursor Division and Prox1 Expression to Promote Lymphatic Identity in Zebrafish." Cell Reports 13.9 (2015): 1828-1841.

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