Kuhlmann L, Göen T, Hiller J (2024)
Publication Type: Journal article
Publication year: 2024
Book Volume: 400
Pages Range: 1-8
DOI: 10.1016/j.toxlet.2024.07.912
2-Ethylhexyl salicylate (EHS) is an organic UV filter which is used in sunscreen and other personal care products. The dermal uptake of EHS was studied in several dermal-exposure experiments. This paper aims to coherently assess urine samples after dermal exposure for the biomarkers EHS, 5OH-EHS, 5oxo-EHS, and 5cx-EPS as well as further biomarkers of interest, specifically 4OH-EHS, 4oxo-EHS, 2OH-EHS, and 6OH-EHS, for the first time. Samples from 18 participants of a pre-existing dermal exposure study under real-life conditions were reassessed using a comprehensive LC-MS/MS method. EHS accounts for 34 % of the cumulative excretion of all analytes within 24 h after exposure, followed by 5OH-EHS (19 %), 5cx-EPS (18 %), 4OH-EHS (15 %) and 5oxo-EHS (11 %). Further metabolites were only quantified in minor amounts. EHS as the most prominent excretion parameter in this study demonstrates the missing first-pass effect after dermal absorption. Furthermore, the applied novel comprehensive analytical procedure revealed oxidation at the ω (5cx-EPS, 6OH-EHS), ω-1 (5OH-EHS, 5oxo-EHS), and ω-2 positions (4OH-EHS, 4oxo-EHS) in the main chain of the ethylhexyl group as well as oxidation in the side chain (2OH-EHS). The presented data are of high relevance for a reliable toxicological risk assessment of dermal exposure to EHS.
APA:
Kuhlmann, L., Göen, T., & Hiller, J. (2024). New metabolites of 2-ethylhexyl salicylate in human urine after simulated real-life dermal sunscreen application. Toxicology Letters, 400, 1-8. https://doi.org/10.1016/j.toxlet.2024.07.912
MLA:
Kuhlmann, Laura, Thomas Göen, and Julia Hiller. "New metabolites of 2-ethylhexyl salicylate in human urine after simulated real-life dermal sunscreen application." Toxicology Letters 400 (2024): 1-8.
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