Time from diagnosis to treatment has no impact on survival in newly diagnosed acute myeloid leukemia treated with venetoclax-based regimens.

Baden D, Zukunft S, Hernandez G, Wolgast N, Steinhauser S, Pohlmann A, Schliemann C, Mikesch JH, Steffen B, Sauer T, Hanoun M, Schafer-Eckart K, Krause S, Hanel M, Einsele H, Jost E, Brummendorf TH, Scholl S, Hochhaus A, Neubauer A, Burchert A, Kaufmann M, Niemann D, Schaich M, Blau W, Kiani A, Gorner M, Kaiser U, Kullmer J, Weber T, Berdel WE, Ehninger G, Muller-Tidow C, Platzbecker U, Serve H, Bornhauser M, Rollig C, Baldus CD, Fransecky L (2024)

Publication Type: Journal article

Publication year: 2024

Journal

Book Volume: 109

Pages Range: 2469-2477

Journal Issue: 8

DOI: 10.3324/haematol.2024.285225

Abstract

In newly diagnosed acute myeloid leukemia (AML), immediate initiation of treatment is standard of care. However, deferral of antileukemic therapy may be indicated to assess comorbidities or pretherapeutic risk factors. We explored the impact of time from diagnosis to treatment on outcomes in newly diagnosed AML undergoing venetoclax-based therapy in two distinct cohorts. By querying the Study Alliance Leukemia database and the global health network TriNetX, we identified 138 and 717 patients respectively with an average age of 76 and 72 years who received venetoclax-based first-line therapy. When comparing patients who started treatment earlier or later than 10 days after initial diagnosis, no significant difference in median overall survival was observed - neither in the SAL cohort (7.7 vs. 9.6 months; P=0.42) nor in the TriNetX cohort (7.5 vs. 7.2 months; P=0.41). Similarly, severe infections, bleeding, and thromboembolic events were equally observed between early and later treatments, both in the overall patient groups and specific subgroups (age ≥75 years or leukocytes ≥20x109/L). This retrospective analysis indicates that delaying the start of venetoclax-based therapy in newly diagnosed AML might be a safe option for selected patients, provided that close clinical monitoring is performed.

Authors with CRIS profile

Involved external institutions

Universitätsklinikum Schleswig-Holstein (UKSH) Germany (DE) Paracelsus Medizinische Privatuniversität, Nürnberg Germany (DE) Universitätsklinikum Aachen (UKA) Germany (DE) HELIOS Kliniken Germany (DE) Klinikum Bielefeld Germany (DE) Universitätsklinikum Frankfurt am Main (KGU) Germany (DE) Universitätsklinikum Heidelberg Germany (DE) Technische Universität Dresden Germany (DE) Universitätsklinikum Leipzig Germany (DE) Universitätsklinikum Würzburg Germany (DE) Universitätsklinikum Jena Germany (DE) Universitätsklinikum Münster Germany (DE) Universitätsklinikum Halle (Saale) Germany (DE) St. Bernward Krankenhaus Germany (DE) Universitätsklinikum Gießen und Marburg (UKGM) Germany (DE) Robert-Bosch-Krankenhaus Germany (DE) Rems-Murr-Kliniken Germany (DE) Universitätsklinikum Essen Germany (DE) Klinikum Chemnitz Germany (DE)

How to cite

APA:

Baden, D., Zukunft, S., Hernandez, G., Wolgast, N., Steinhauser, S., Pohlmann, A.,... Fransecky, L. (2024). Time from diagnosis to treatment has no impact on survival in newly diagnosed acute myeloid leukemia treated with venetoclax-based regimens. Haematologica, 109(8), 2469-2477. https://doi.org/10.3324/haematol.2024.285225

MLA:

Baden, David, et al. "Time from diagnosis to treatment has no impact on survival in newly diagnosed acute myeloid leukemia treated with venetoclax-based regimens." Haematologica 109.8 (2024): 2469-2477.

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