Cocrystal formulation design of 4-Aminosalicylic acid and isoniazid via spray-drying based on a ternary phase diagram toward simultaneous pulmonary delivery
Mo P, Hatanaka Y, Furukawa S, Takase M, Yamanaka S, Doi M, Kämäräinen T, Uchiyama H, Kadota K, Tozuka Y (2024)
Publication Type: Journal article
Publication year: 2024
Journal
Pages Range: 120126
Article Number: 120126
DOI: 10.1016/j.powtec.2024.120126
Abstract
Cocrystal engineering is a potent strategy for enhancing drug properties, but its application in spray-drying has been limited. Furthermore, concurrently introducing two drugs and realizing simultaneous pharmacological effects at the target site is challenging. This is particularly evident for oral formulations designed for systemic use, but the local administration of drugs at the target site displays the potential to overcome this problem. Herein, we investigated the potential of cocrystallization principles for use in developing dry powder inhaler formulations of anti-tuberculosis drugs. We focused on the formation of cocrystals of 4-aminosalicylic acid (PAS) and isoniazid (INH), which are crucial components of tuberculosis treatment. Via spray-drying, we successfully produced spray-dried particles of PAS-INH that exhibited hydrogen bonding interactions between the molecules. Aerosolization performance evaluation with an Andersen Cascade Impactor (ACI) confirmed the concurrent deposition of both drugs, highlighting the potential of our particle design for use in the co-delivery of PAS-INH. Furthermore, simulated lung dissolution studies using the ACI and Transwell inserts revealed synchronized dissolution patterns, indicating promising prospects for use in effective drug delivery. This innovative approach to tuberculosis therapy has significant implications for improving treatment efficacy and enhancing patient adherence, potentially revolutionizing tuberculosis treatment.
Authors with CRIS profile
Involved external institutions
Osaka Medical and Pharmaceutical University
Japan (JP)
Muroran Institute of Technology (MuIT) / 室蘭工業大学
Japan (JP)
Japan (JP)
Muroran Institute of Technology (MuIT) / 室蘭工業大学
Japan (JP)
How to cite
APA:
Mo, P., Hatanaka, Y., Furukawa, S., Takase, M., Yamanaka, S., Doi, M.,... Tozuka, Y. (2024). Cocrystal formulation design of 4-Aminosalicylic acid and isoniazid via spray-drying based on a ternary phase diagram toward simultaneous pulmonary delivery. Powder Technology, 120126. https://doi.org/10.1016/j.powtec.2024.120126
MLA:
Mo, Peiwen, et al. "Cocrystal formulation design of 4-Aminosalicylic acid and isoniazid via spray-drying based on a ternary phase diagram toward simultaneous pulmonary delivery." Powder Technology (2024): 120126.
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