Accessories to the crime: Recent advances in HIV accessory protein biology
Gramberg T, Sunseri N, Landau NR (2009)
Publication Type: Journal article, Review article
Publication year: 2009
Journal
Book Volume: 6
Pages Range: 36-42
Journal Issue: 1
DOI: 10.1007/s11904-009-0006-z
Abstract
Recent advances in understanding the roles of the lentiviral accessory proteins have provided fascinating insight into the molecular biology of the virus and uncovered previously unappreciated innate immune mechanisms by which the host defends itself. HIV-1 and other lentiviruses have developed accessory proteins that counterattack the antiviral defenses in a sort of evolutionary battle. The virus is remarkably adept at co-opting cellular degradative pathways to destroy the protective proteins. This review focuses on recent advances in understanding three of the accessory proteins - virion infectivity factor (Vif), viral protein R (Vpr), and viral protein U (Vpu) - that target different restriction factors to ensure virus replication. These proteins may provide promising targets for the development of novel classes of antiretroviral drugs. Copyright © 2009 by Current Medicine Group LLC.
Involved external institutions
United States (USA) (US)How to cite
APA:
Gramberg, T., Sunseri, N., & Landau, N.R. (2009). Accessories to the crime: Recent advances in HIV accessory protein biology. Current HIV/AIDS Reports, 6(1), 36-42. https://doi.org/10.1007/s11904-009-0006-z
MLA:
Gramberg, Thomas, Nicole Sunseri, and Nathaniel R. Landau. "Accessories to the crime: Recent advances in HIV accessory protein biology." Current HIV/AIDS Reports 6.1 (2009): 36-42.
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