European Neuroendocrine Tumor Society (ENETS) 2024 guidance paper for the management of well-differentiated small intestine neuroendocrine tumours
Lamarca A, Bartsch DK, Caplin M, Kos-Kudla B, Kjaer A, Partelli S, Rinke A, Janson ET, Thirlwell C, van Velthuysen MLF, Vullierme MP, Pavel ME (2024)
Publication Type: Journal article
Publication year: 2024
Journal
DOI: 10.1111/jne.13423
Abstract
Both the incidence and prevalence of well-differentiated neuroendocrine tumours from the small intestine (Si-NET) are gradually increasing. Most patients have non-functioning tumours with subtle GI symptoms and tumours are often discovered incidentally by endoscopy or at advanced disease stages by imaging depicting mesenteric lymph node and /or liver metastases while around 30% of the patients present with symptoms of the carcinoid syndrome. Adequate biochemical assessment and staging including functional imaging is crucial for treatment-related decision-making that should take place in an expert multidisciplinary team setting. Preferably, patients should be referred to specialised ENETS Centres of Excellence or centres of high expertise in the field. This guidance paper provides the current evidence and best knowledge for the management of Si-NET grade (G) 1–3 following 10 key questions of practical relevance for the diagnostic and therapeutic decision making.
Authors with CRIS profile
Involved external institutions
Uppsala University
Sweden (SE)
Hôpital Paul-Brousse
France (FR)
Hospital Universitario Fundación Jiménez Díaz
Spain (ES)
Philipps-Universität Marburg
Germany (DE)
Royal Free Hospital
United Kingdom (GB)
Medical University of Silesia in Katowice / Śląski Uniwersytet Medyczny w Katowicach (SUM)
Poland (PL)
Rigshospitalet
Denmark (DK)
Università Vita-Salute San Raffaele (UniSR)
Italy (IT)
Universitätsklinikum Gießen und Marburg (UKGM)
Germany (DE)
University of Exeter
United Kingdom (GB)
Erasmus University Medical Center (MC)
Netherlands (NL)
Sweden (SE)
Hôpital Paul-Brousse
France (FR)
Hospital Universitario Fundación Jiménez Díaz
Spain (ES)
Philipps-Universität Marburg
Germany (DE)
Royal Free Hospital
United Kingdom (GB)
Medical University of Silesia in Katowice / Śląski Uniwersytet Medyczny w Katowicach (SUM)
Poland (PL)
Rigshospitalet
Denmark (DK)
Università Vita-Salute San Raffaele (UniSR)
Italy (IT)
Universitätsklinikum Gießen und Marburg (UKGM)
Germany (DE)
University of Exeter
United Kingdom (GB)
Erasmus University Medical Center (MC)
Netherlands (NL)
How to cite
APA:
Lamarca, A., Bartsch, D.K., Caplin, M., Kos-Kudla, B., Kjaer, A., Partelli, S.,... Pavel, M.E. (2024). European Neuroendocrine Tumor Society (ENETS) 2024 guidance paper for the management of well-differentiated small intestine neuroendocrine tumours. Journal of Neuroendocrinology. https://doi.org/10.1111/jne.13423
MLA:
Lamarca, Angela, et al. "European Neuroendocrine Tumor Society (ENETS) 2024 guidance paper for the management of well-differentiated small intestine neuroendocrine tumours." Journal of Neuroendocrinology (2024).
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