The Therapeutic Potential and Molecular Mechanisms Underlying the Neuroprotective Effects of Sativex® - A Cannabis-derived Spray

Motamedy S, Soltani B, Kameshki H, Kermani AA, Amleshi RS, Nazeri Rezaabad M, Shabani M (2024)

Publication Language: English

Publication Type: Journal article, Review article

Publication year: 2024

Journal

Mini-Reviews in Medicinal Chemistry Bentham Science Publishers

Book Volume: 24

Pages Range: 1427-1448

Journal Issue: 15

DOI: 10.2174/0113895575285934240123110158

Abstract

Sativex is a cannabis-based medicine that comes in the form of an oromucosal spray. It contains equal amounts of Δ9-tetrahydrocannabinol and cannabidiol, two compounds derived from cannabis plants. Sativex has been shown to have positive effects on symptoms of amyotrophic lateral sclerosis (ALS), multiple sclerosis (MS), and sleep disorders. It also has analgesic, antiinflammatory, antitumoral, and neuroprotective properties, which make it a potential treatment option for other neurological disorders. The article reviews the results of recent preclinical and clinical studies that support the therapeutic potential of Sativex and the molecular mechanisms behind its neuroprotective benefits in various neurological disorders. The article also discusses the possible advantages and disadvantages of using Sativex as a neurotherapeutic agent, such as its safety, efficacy, availability, and legal status.

Authors with CRIS profile

Masoud Nazeri Rezaabad Department of Anaesthesiology

Involved external institutions

Kerman University of Medical Sciences / Kerman Medical University IR Iran, Islamic Republic of (IR) Shahid Bahonar University of Kerman (SBUK) / دانشگاه شهيد باهنر کرمان IR Iran, Islamic Republic of (IR)

How to cite

APA:

Motamedy, S., Soltani, B., Kameshki, H., Kermani, A.A., Amleshi, R.S., Nazeri Rezaabad, M., & Shabani, M. (2024). The Therapeutic Potential and Molecular Mechanisms Underlying the Neuroprotective Effects of Sativex® - A Cannabis-derived Spray. Mini-Reviews in Medicinal Chemistry, 24(15), 1427-1448. https://doi.org/10.2174/0113895575285934240123110158

MLA:

Motamedy, Sina, et al. "The Therapeutic Potential and Molecular Mechanisms Underlying the Neuroprotective Effects of Sativex® - A Cannabis-derived Spray." Mini-Reviews in Medicinal Chemistry 24.15 (2024): 1427-1448.

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