Anti-angiogenic therapy in head and neck squamous cell carcinoma - current limitations and future directions
Nieberle F, Spoerl S, Głuszko A, Taxis J, Spanier G, Erber R, Spörl S, Szczepański MJ, Beckhove P, Reichert TE, Whiteside TL, Ludwig N (2024)
Publication Type: Journal article, Review article
Publication year: 2024
Journal
Book Volume: 8
Article Number: 25
DOI: 10.20517/2574-1209.2023.73
Abstract
Angiogenesis, the formation of new blood vessels, plays a crucial role in the progression and metastasis of various cancers, including head and neck squamous cell carcinoma (HNSCC). HNSCCs are characterized by altered levels of angiogenesis-related factors, including the overexpression of pro-angiogenic factors such as vascular endothelial growth factor (VEGF) and platelet-derived growth factor (PDGF), as well as the dysregulation of angiogenesis inhibitors. Together, these factors drive the formation of new blood vessels within the tumor microenvironment and are considered therapeutic targets in HNSCC. Although preclinical studies are promising, challenges have emerged in the clinical use of anti-angiogenic agents in the clinic, including treatment-related toxicities and the development of resistance to therapy. There is an unmet need for further research to elucidate the molecular pathways involved in HNSCC angiogenesis, identify novel therapeutic targets, and discover predictive biomarkers to improve patient selection.
Authors with CRIS profile
Ramona Erber
Institute of Pathology
Silvia Spörl
Department of Medicine 5 – Haematology and Oncology
Involved external institutions
Universitätsklinikum Regensburg
Germany (DE)
Wrocław Medical University / Uniwersytet Medyczny we Wrocławiu
Poland (PL)
Leibniz-Institut für Immuntherapie (LIT) / Leibniz Institute for Immunotherapy
Germany (DE)
University of Pittsburgh
United States (USA) (US)
Germany (DE)
Wrocław Medical University / Uniwersytet Medyczny we Wrocławiu
Poland (PL)
Leibniz-Institut für Immuntherapie (LIT) / Leibniz Institute for Immunotherapy
Germany (DE)
University of Pittsburgh
United States (USA) (US)
How to cite
APA:
Nieberle, F., Spoerl, S., Głuszko, A., Taxis, J., Spanier, G., Erber, R.,... Ludwig, N. (2024). Anti-angiogenic therapy in head and neck squamous cell carcinoma - current limitations and future directions. Vessel Plus, 8. https://doi.org/10.20517/2574-1209.2023.73
MLA:
Nieberle, Felix, et al. "Anti-angiogenic therapy in head and neck squamous cell carcinoma - current limitations and future directions." Vessel Plus 8 (2024).
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