Measuring Concentration of Nanoparticles in Polydisperse Mixtures Using Interferometric Nanoparticle Tracking Analysis

Kashkanova AD, Albrecht D, Küppers M, Blessing M, Sandoghdar V (2024)

Publication Type: Journal article

Publication year: 2024

Journal

ACS nano American Chemical Society

DOI: 10.1021/acsnano.4c04396

Abstract

Quantitative measurements of nanoparticle concentration in liquid suspensions are in high demand, for example, in the medical and food industries. Conventional methods remain unsatisfactory, especially for polydisperse samples with overlapping size ranges. Recently, we introduced interferometric nanoparticle tracking analysis (iNTA) for high-precision measurement of nanoparticle size and refractive index. Here, we show that by counting the number of trajectories that cross the focal plane, iNTA can measure concentrations of subpopulations in a polydisperse mixture in a quantitative manner and without the need for a calibration sample. We evaluate our method on both monodisperse samples and mixtures of known concentrations. Furthermore, we assess the concentration of SARS-CoV-2 in supernatant samples obtained from infected cells.

Authors with CRIS profile

Vahid Sandoghdar

Involved external institutions

Max-Planck-Institut für die Physik des Lichts (MPL) / Max Planck Institute for the Science of Light DE Germany (DE)

How to cite

APA:

Kashkanova, A.D., Albrecht, D., Küppers, M., Blessing, M., & Sandoghdar, V. (2024). Measuring Concentration of Nanoparticles in Polydisperse Mixtures Using Interferometric Nanoparticle Tracking Analysis. ACS nano. https://doi.org/10.1021/acsnano.4c04396

MLA:

Kashkanova, Anna D., et al. "Measuring Concentration of Nanoparticles in Polydisperse Mixtures Using Interferometric Nanoparticle Tracking Analysis." ACS nano (2024).

BibTeX: Download