Variable Clinical Courses of Varicella Zoster Virus Infection–related or Vaccination-related Bone Marrow Failure
Toskov V, Cseh A, Claviez A, Drexler B, Rotari N, Schwarz-Furlan S, Braun M, Bader P, Lang P, Beier R, Erdlenbruch B, Führer M, Erlacher M, Niemeyer CM, Strahm B, Yoshimi A (2024)
Publication Type: Journal article
Publication year: 2024
Journal
Book Volume: 46
Pages Range: e354-e359
Journal Issue: 5
DOI: 10.1097/MPH.0000000000002866
Abstract
We report 5 children with bone marrow failure (BMF) after primary varicella zoster virus (VZV) infection or VZV vaccination, highlighting the highly variable course. Two patients were treated with intravenous immunoglobulins; one had a slow hematologic recovery, and the other was rescued by allogeneic hematopoietic stem cell transplantation (HSCT). Of the 2 patients treated with immunosuppressive therapy with antithymocyte globulin and cyclosporine, one had a complete response, and the other was transplanted for nonresponse. One patient underwent a primary allograft. All patients are alive. This study demonstrated that VZV-associated BMF is a life-threatening disorder that often requires HSCT.
Involved external institutions
Universitätsklinikum Schleswig-Holstein (UKSH)
Germany (DE)
Albert-Ludwigs-Universität Freiburg
Germany (DE)
Kliniken Ostallgäu-Kaufbeuren Anstalt des öffentlichen Rechts Buchloe - Füssen - Kaufbeuren
Germany (DE)
Justus-Liebig-Universität Gießen
Germany (DE)
Universitätsklinikum Frankfurt am Main (KGU)
Germany (DE)
Universitätsklinikum Tübingen
Germany (DE)
Medizinische Hochschule Hannover (MHH) / Hannover Medical School
Germany (DE)
Johannes Wesling Klinikum Minden
Germany (DE)
Klinikum der Universität München
Germany (DE)
Germany (DE)
Albert-Ludwigs-Universität Freiburg
Germany (DE)
Kliniken Ostallgäu-Kaufbeuren Anstalt des öffentlichen Rechts Buchloe - Füssen - Kaufbeuren
Germany (DE)
Justus-Liebig-Universität Gießen
Germany (DE)
Universitätsklinikum Frankfurt am Main (KGU)
Germany (DE)
Universitätsklinikum Tübingen
Germany (DE)
Medizinische Hochschule Hannover (MHH) / Hannover Medical School
Germany (DE)
Johannes Wesling Klinikum Minden
Germany (DE)
Klinikum der Universität München
Germany (DE)
How to cite
APA:
Toskov, V., Cseh, A., Claviez, A., Drexler, B., Rotari, N., Schwarz-Furlan, S.,... Yoshimi, A. (2024). Variable Clinical Courses of Varicella Zoster Virus Infection–related or Vaccination-related Bone Marrow Failure. Journal of Pediatric Hematology Oncology, 46(5), e354-e359. https://doi.org/10.1097/MPH.0000000000002866
MLA:
Toskov, Vasil, et al. "Variable Clinical Courses of Varicella Zoster Virus Infection–related or Vaccination-related Bone Marrow Failure." Journal of Pediatric Hematology Oncology 46.5 (2024): e354-e359.
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