Do Not Forget the Granulocytic Compartment's Role in T cell-Mediated Antitumor Immunity

Gaipl U (2024)


Publication Type: Journal article

Publication year: 2024

Journal

Book Volume: 12

Pages Range: 798-799

Journal Issue: 7

DOI: 10.1158/2326-6066.CIR-24-0395

Abstract

Antitumor immune responses are predominantly mediated by CD8+ cytotoxic T cells (CTLs). But immune-modulatory factors in the tumor microenvironment determine the effectiveness of these responses. In this issue, Wei and colleagues report a new role for CTL-derived IL3 in stimulating basophilic granulocytes to produce IL4, which, in turn, activates, reprograms, and stabilizes CTLs. These findings stress the importance of the crosstalk between the innate and adaptive immune systems to elicit efficient antitumor immunity. See related article by Wei et al., p. 822 (3).

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How to cite

APA:

Gaipl, U. (2024). Do Not Forget the Granulocytic Compartment's Role in T cell-Mediated Antitumor Immunity. Cancer Immunology Research, 12(7), 798-799. https://doi.org/10.1158/2326-6066.CIR-24-0395

MLA:

Gaipl, Udo. "Do Not Forget the Granulocytic Compartment's Role in T cell-Mediated Antitumor Immunity." Cancer Immunology Research 12.7 (2024): 798-799.

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