Gender differences in patient experience in idiopathic inflammatory myopathies: Subanalysis from the COVAD dataset.

Yoshida A, Kim M, Kuwana M, Ravichandran N, Makol A, Sen P, Lilleker JB, Agarwal V, Kardes S, Day J, Milchert M, Joshi M, Gheita T, Salim B, Velikova T, Gracia-Ramos AE, Parodis I, Nikiphorou E, Chatterjee T, Tan AL, Nune A, Cavagna L, Saavedra MA, Shinjo SK, Ziade N, Knitza J, Distler O, Chinoy H, Agarwal V, Aggarwal R, Gupta L, Barman B, Singh YP, Ranjan R, Jain A, Pandya SC, Pilania RK, Sharma A, Manesh Manoj M, Gupta V, Kavadichanda CG, Patro PS, Ajmani S, Phatak S, Goswami RP, Chowdhury AC, Mathew AJ, Shenoy P, Asranna A, Bommakanti KT, Shukla A, Pande AR, Chandwar K, Cansu DÜ, Pauling JD, Wincup C, Del Papa N, Sambataro G, Fabiola A, Govoni M, Parisi S, Bocci EB, Sebastiani GD, Fusaro E, Sebastiani M, Quartuccio L, Franceschini F, Sainaghi PP, Orsolini G, De Angelis R, Danielli MG, Venerito V, Traboco LS, Wibowo SAK, Serrano JR, García-De La Torre I, Tehozol EAZ, Loarce-Martos J, Prieto-González S, Gil-Vila A, Gonzalez RA, Nakashima R, Sato S, Kimura N, Kaneko Y, Tomaras S, Gromova MA, Aharonov O, Hmamouchi I, Hoff LS, Giannini M, Maurier F, Campagne J, Meyer A, Nagy-Vincze M, Langguth D, Limaye V, Needham M, Srivastav N, Hudson M, Landon-Cardinal O, Shaharir SS, Zuleta WGR, Silva JAP, Fonseca JE, Zimba O (2024)

Publication Type: Journal article

Publication year: 2024

Journal

Book Volume: 34

Pages Range: 756-766

Journal Issue: 4

DOI: 10.1093/mr/road094

Abstract

OBJECTIVES: We aimed to investigate the gender-based differences in idiopathic inflammatory myopathies (IIMs), with a particular focus on patient-reported outcomes, utilizing the data obtained through the international COVID-19 vaccination in autoimmune disease e-survey. METHODS: Patient-reported outcomes including fatigue, pain, and physical function were extracted from the COVID-19 vaccination in autoimmune disease database and compared between genders, adjusting for demographics and IIM subgroups by multivariable analysis. Inclusion body myositis (IBM) was analysed separately because of the substantial differences in outcomes. RESULTS: A total of 1197 complete responses from patients with IIMs as of 31 August 2021 were analysed. Seventy percent were women. Women were younger (58 [48-68] vs. 69 [58-75] years old, median [interquartile range], P < .001) and were more likely to suffer from autoimmune multimorbidity, defined as three or more autoimmune diseases in an individual patient (11.4% vs. 2.8%, P < .001). In non-IBM IIMs, fatigue visual analogue scale scores were higher in women (5 [3-7] vs. 4 [2-6], median [interquartile range], P = .004), whereas no significant gender-based differences were noted in IBM. Multivariable analysis in non-IBM IIMs revealed that women, residence in high-income countries, overlap myositis, and autoimmune multimorbidity were independently associated with increased fatigue. CONCLUSIONS: Women with IIMs suffer from autoimmune multimorbidity and experience increased fatigue compared to men.

Authors with CRIS profile

Involved external institutions

University of Manchester United Kingdom (GB) Karolinska University Hospital / Karolinska Universitetssjukhuset Sweden (SE) University of Illinois at Urbana-Champaign United States (USA) (US) Sanjay Gandhi Post Graduate Institute of Medical Sciences (SGPGIMS) India (IN) Mayo Clinic United States (USA) (US) Maulana Azad Medical College (MAMC) India (IN) Mahatma Gandhi Mission Medical College and Hospital India (IN) Istanbul University / İstanbul Üniversitesi Turkey (TR) Royal Melbourne Hospital (RMH) Australia (AU) Pomeranian Medical University / Pomorski Uniwersytet Medyczny w Szczecinie (PMU) Poland (PL) Byramjee Jeejeebhoy Government Medical College & Sassoon General Hospital India (IN) Fauji Foundation Hospital Pakistan (PK) Sofia University "St. Kliment Ohridski" / Софийски университет "Св. Климент Охридски" Bulgaria (BG) Instituto Mexicano del Seguro Social Mexico (MX) King’s College London United Kingdom (GB) Policlinico San Matteo Pavia Fondazione IRCCS Italy (IT) Centro Medico Nacional Siglo XXI Mexico (MX) University of São Paulo / Universidade de São Paulo (USP) Brazil (BR) Université Saint-Joseph (USJ) / جامعة القديس يوسف / Սուրբ Ժոզեֆի համալսարան Lebanon (LB) Universitätsspital Zürich (USZ) Switzerland (CH) University of Pittsburgh United States (USA) (US) NIHR Leeds Musculoskeletal Biomedical Research Unit (LMBRU) United Kingdom (GB) Southport and Ormskirk Hospital NHS Trust United Kingdom (GB)

How to cite

APA:

Yoshida, A., Kim, M., Kuwana, M., Ravichandran, N., Makol, A., Sen, P.,... Zimba, O. (2024). Gender differences in patient experience in idiopathic inflammatory myopathies: Subanalysis from the COVAD dataset. Modern Rheumatology, 34(4), 756-766. https://doi.org/10.1093/mr/road094

MLA:

Yoshida, Akira, et al. "Gender differences in patient experience in idiopathic inflammatory myopathies: Subanalysis from the COVAD dataset." Modern Rheumatology 34.4 (2024): 756-766.

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