The ReCoDe addiction research consortium: Losing and regaining control over drug intake—Findings and future perspectives

Spanagel R, Bach P, Banaschewski T, Beck A, Bermpohl F, Bernardi RE, Beste C, Deserno L, Durstewitz D, Ebner-Priemer U, Endrass T, Ersche KD, Feld G, Gerchen MF, Gerlach B, Goschke T, Hansson AC, Heim C, Kiebel S, Kiefer F, Kirsch P, Kirschbaum C, Koppe G, Lenz B, Liu S, Marxen M, Meinhardt MW, Meyer-Lindenberg A, Montag C, Müller CP, Nagel WE, Oliveria AM, Owald D, Pilhatsch M, Priller J, Rapp MA, Reichert M, Ripke S, Ritter K, Romanczuk-Seiferth N, Schlagenhauf F, Schwarz E, Schwöbel S, Smolka MN, Soekadar SR, Sommer WH, Stock AK, Ströhle A, Tost H, Vollstädt-Klein S, Walter H, Waschke T, Witt SH, Heinz A (2024)

Publication Type: Journal article, Review article

Publication year: 2024

Journal

Addiction Biology Wiley-Blackwell

Book Volume: 29

Article Number: e13419

Journal Issue: 7

DOI: 10.1111/adb.13419

Abstract

Substance use disorders (SUDs) are seen as a continuum ranging from goal-directed and hedonic drug use to loss of control over drug intake with aversive consequences for mental and physical health and social functioning. The main goals of our interdisciplinary German collaborative research centre on Losing and Regaining Control over Drug Intake (ReCoDe) are (i) to study triggers (drug cues, stressors, drug priming) and modifying factors (age, gender, physical activity, cognitive functions, childhood adversity, social factors, such as loneliness and social contact/interaction) that longitudinally modulate the trajectories of losing and regaining control over drug consumption under real-life conditions. (ii) To study underlying behavioural, cognitive and neurobiological mechanisms of disease trajectories and drug-related behaviours and (iii) to provide non-invasive mechanism-based interventions. These goals are achieved by: (A) using innovative mHealth (mobile health) tools to longitudinally monitor the effects of triggers and modifying factors on drug consumption patterns in real life in a cohort of 900 patients with alcohol use disorder. This approach will be complemented by animal models of addiction with 24/7 automated behavioural monitoring across an entire disease trajectory; i.e. from a naïve state to a drug-taking state to an addiction or resilience-like state. (B) The identification and, if applicable, computational modelling of key molecular, neurobiological and psychological mechanisms (e.g., reduced cognitive flexibility) mediating the effects of such triggers and modifying factors on disease trajectories. (C) Developing and testing non-invasive interventions (e.g., Just-In-Time-Adaptive-Interventions (JITAIs), various non-invasive brain stimulations (NIBS), individualized physical activity) that specifically target the underlying mechanisms for regaining control over drug intake. Here, we will report on the most important results of the first funding period and outline our future research strategy.

Involved external institutions

Zentralinstitut für Seelische Gesundheit DE Germany (DE) Universitätsklinikum Mannheim DE Germany (DE) Charité - Universitätsmedizin Berlin DE Germany (DE) Technische Universität Dresden DE Germany (DE) Universität Potsdam DE Germany (DE) Technische Universität München (TUM) DE Germany (DE) Universitätsklinikum Würzburg DE Germany (DE) Karlsruhe Institute of Technology (KIT) DE Germany (DE) MSB Medical School Berlin – Hochschule für Gesundheit und Medizin DE Germany (DE)

How to cite

APA:

Spanagel, R., Bach, P., Banaschewski, T., Beck, A., Bermpohl, F., Bernardi, R.E.,... Heinz, A. (2024). The ReCoDe addiction research consortium: Losing and regaining control over drug intake—Findings and future perspectives. Addiction Biology, 29(7). https://doi.org/10.1111/adb.13419

MLA:

Spanagel, Rainer, et al. "The ReCoDe addiction research consortium: Losing and regaining control over drug intake—Findings and future perspectives." Addiction Biology 29.7 (2024).

BibTeX: Download