Hodgkin lymphoma: hypodense lesions in mediastinal masses

Damek A, Kurch L, Franke FC, Attarbaschi A, Beishuizen A, Cepelova M, Ceppi F, Daw S, Dieckmann K, Fernández-Teijeiro A, Feuchtinger T, Flerlage JE, Fosså A, Georgi TW, Hasenclever D, Hraskova A, Karlen J, Klekawka T, Kluge R, Körholz D, Landman-Parker J, Leblanc T, Mauz-Körholz C, Metzler M, Pears J, Steglich J, Uyttebroeck A, Vordermark D, Wallace WH, Wohlgemuth WA, Stoevesandt D (2024)

Publication Type: Journal article

Publication year: 2024

Journal

Book Volume: 14

Article Number: 14591

Journal Issue: 1

DOI: 10.1038/s41598-024-64253-8

Abstract

Hypodense volumes (HDV) in mediastinal masses can be visualized in a computed tomography scan in Hodgkin lymphoma. We analyzed staging CT scans of 1178 patients with mediastinal involvement from the EuroNet-PHL-C1 trial and explored correlations of HDV with patient characteristics, mediastinal tumor volume and progression-free survival. HDV occurred in 350 of 1178 patients (29.7%), typically in larger mediastinal volumes. There were different patterns in appearance with single lesions found in 243 patients (69.4%), multiple lesions in 107 patients (30.6%). Well delineated lesions were found in 248 cases (70.1%), diffuse lesions were seen in 102 cases (29.1%). Clinically, B symptoms occurred more often in patients with HDV (47.7% compared to 35.0% without HDV (p = 0.039)) and patients with HDV tended to be in higher risk groups. Inadequate overall early-¹⁸F-FDG-PET-response was strongly correlated with the occurrence of hypodense lesions (p < 0.001). Patients with total HDV > 40 ml (n = 80) had a 5 year PFS of 79.6% compared to 89.7% (p = 0.01) in patients with HDV < 40 ml or no HDV. This difference in PFS is not caused by treatment group alone. HDV is a common phenomenon in HL with mediastinal involvement.

Authors with CRIS profile

Involved external institutions

St. Jude Children’s Research Hospital United States (USA) (US) Oslo University Hospital / Oslo Universitetssykehus Rikshospitalet Norway (NO) Universität Leipzig Germany (DE) National Institute of Children’s Diseases (NÚDCH) Slovakia (SK) Karolinska University Hospital / Karolinska Universitetssjukhuset Sweden (SE) University Children’s Hospital / Uniwersytecki Szpital Dziecięcy Poland (PL) Universität Leipzig Germany (DE) Justus-Liebig-Universität Gießen Germany (DE) Hôpital Armand-Trousseau (AP-HP) France (FR) Hôpital Universitaire Robert-Debré France (FR) Justus-Liebig-Universität Gießen Germany (DE) Temple Street Children's University Hospital / Children's Health Ireland (CHI) Ireland (IE) Universitätsklinikum Halle (Saale) Germany (DE) University Hospital Leuven (UZ) / Universitaire ziekenhuizen Leuven Belgium (BE) Universitätsklinikum Halle (Saale) Germany (DE) University of Edinburgh United Kingdom (GB) Medizinische Universität Wien Austria (AT) Erasmus MC - Sophia Children’s Hospital Netherlands (NL) Univerzita Karlova v Praze / Charles University in Prague Czech Republic (CZ) Lausanne University Hospital / Centre hospitalier universitaire vaudois (CHUV) Switzerland (CH) University College London Hospitals (UCLH) United Kingdom (GB) Vienna General Hospital / Allgemeines Krankenhaus der Stadt Wien (AKH) Austria (AT) Hospitales Universitarios Virgen Macarena y Virgen del Rocío Spain (ES) Klinikum der Universität München (LMU Klinikum) Germany (DE)

How to cite

APA:

Damek, A., Kurch, L., Franke, F.C., Attarbaschi, A., Beishuizen, A., Cepelova, M.,... Stoevesandt, D. (2024). Hodgkin lymphoma: hypodense lesions in mediastinal masses. Scientific Reports, 14(1). https://doi.org/10.1038/s41598-024-64253-8

MLA:

Damek, Adrian, et al. "Hodgkin lymphoma: hypodense lesions in mediastinal masses." Scientific Reports 14.1 (2024).

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