Hodgkin lymphoma: hypodense lesions in mediastinal masses

Damek A, Kurch L, Franke FC, Attarbaschi A, Beishuizen A, Cepelova M, Ceppi F, Daw S, Dieckmann K, Fernández-Teijeiro A, Feuchtinger T, Flerlage JE, Fosså A, Georgi TW, Hasenclever D, Hraskova A, Karlen J, Klekawka T, Kluge R, Körholz D, Landman-Parker J, Leblanc T, Mauz-Körholz C, Metzler M, Pears J, Steglich J, Uyttebroeck A, Vordermark D, Wallace WH, Wohlgemuth WA, Stoevesandt D (2024)

Publication Type: Journal article

Publication year: 2024

Journal

Book Volume: 14

Article Number: 14591

Journal Issue: 1

DOI: 10.1038/s41598-024-64253-8

Abstract

Hypodense volumes (HDV) in mediastinal masses can be visualized in a computed tomography scan in Hodgkin lymphoma. We analyzed staging CT scans of 1178 patients with mediastinal involvement from the EuroNet-PHL-C1 trial and explored correlations of HDV with patient characteristics, mediastinal tumor volume and progression-free survival. HDV occurred in 350 of 1178 patients (29.7%), typically in larger mediastinal volumes. There were different patterns in appearance with single lesions found in 243 patients (69.4%), multiple lesions in 107 patients (30.6%). Well delineated lesions were found in 248 cases (70.1%), diffuse lesions were seen in 102 cases (29.1%). Clinically, B symptoms occurred more often in patients with HDV (47.7% compared to 35.0% without HDV (p = 0.039)) and patients with HDV tended to be in higher risk groups. Inadequate overall early-¹⁸F-FDG-PET-response was strongly correlated with the occurrence of hypodense lesions (p < 0.001). Patients with total HDV > 40 ml (n = 80) had a 5 year PFS of 79.6% compared to 89.7% (p = 0.01) in patients with HDV < 40 ml or no HDV. This difference in PFS is not caused by treatment group alone. HDV is a common phenomenon in HL with mediastinal involvement.

Authors with CRIS profile

Involved external institutions

Universitätsklinikum Halle (Saale) Germany (DE) St. Jude Children’s Research Hospital United States (USA) (US) Oslo University Hospital / Oslo Universitetssykehus Rikshospitalet Norway (NO) Universität Leipzig Germany (DE) National Institute of Children’s Diseases (NÚDCH) Slovakia (SK) Karolinska University Hospital / Karolinska Universitetssjukhuset Sweden (SE) University Children’s Hospital / Uniwersytecki Szpital Dziecięcy Poland (PL) Justus-Liebig-Universität Gießen Germany (DE) Hôpital Armand-Trousseau (AP-HP) France (FR) Hôpital Universitaire Robert-Debré France (FR) Temple Street Children's University Hospital / Children's Health Ireland (CHI) Ireland (IE) Medizinische Universität Wien Austria (AT) University Hospital Leuven (UZ) / Universitaire ziekenhuizen Leuven Belgium (BE) Erasmus MC - Sophia Children’s Hospital Netherlands (NL) Univerzita Karlova v Praze / Charles University in Prague Czech Republic (CZ) University of Edinburgh United Kingdom (GB) Lausanne University Hospital / Centre hospitalier universitaire vaudois (CHUV) Switzerland (CH) University College London Hospitals (UCLH) United Kingdom (GB) Vienna General Hospital / Allgemeines Krankenhaus der Stadt Wien (AKH) Austria (AT) Hospitales Universitarios Virgen Macarena y Virgen del Rocío Spain (ES) Klinikum der Universität München Germany (DE)

How to cite

APA:

Damek, A., Kurch, L., Franke, F.C., Attarbaschi, A., Beishuizen, A., Cepelova, M.,... Stoevesandt, D. (2024). Hodgkin lymphoma: hypodense lesions in mediastinal masses. Scientific Reports, 14(1). https://doi.org/10.1038/s41598-024-64253-8

MLA:

Damek, Adrian, et al. "Hodgkin lymphoma: hypodense lesions in mediastinal masses." Scientific Reports 14.1 (2024).

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