Distinct metabolomic and lipidomic profiles in serum samples of patients with primary sclerosing cholangitis

Fererberger T, Buechler C, Kandulski A, Elger T, Loibl J, Schmid S, Sommersberger S, Gunawan S, Zundler S, Huss M, Bettenworth D, Kempa S, Weidlich S, Föh B, Huang X, Grzegorzek M, Derer-Petersen S, Günther UL, Marquardt JU, Kunst C, Gülow K, Müller M, Sina C, Schmelter F, Tews HC (2024)

Publication Type: Journal article

Publication year: 2024

Journal

Frontiers in Medicine Frontiers Media

Book Volume: 11

Article Number: 1334865

DOI: 10.3389/fmed.2024.1334865

Abstract

Intoduction: Identification of specific metabolome and lipidome profile of patients with primary sclerosing cholangitis (PSC) is crucial for diagnosis, targeted personalized therapy, and more accurate risk stratification. Methods: Nuclear magnetic resonance (NMR) spectroscopy revealed an altered metabolome and lipidome of 33 patients with PSC [24 patients with inflammatory bowel disease (IBD) and 9 patients without IBD] compared with 40 age-, sex-, and body mass index (BMI)-matched healthy controls (HC) as well as 64 patients with IBD and other extraintestinal manifestations (EIM) but without PSC. Results: In particular, higher concentrations of pyruvic acid and several lipoprotein subfractions were measured in PSC in comparison to HC. Of clinical relevance, a specific amino acid and lipid profile was determined in PSC compared with IBD and other EIM. Discussion: These results have the potential to improve diagnosis by differentiating PSC patients from HC and those with IBD and EIM.

Authors with CRIS profile

Sebastian Zundler Department of Medicine 1 – Gastroenterology, Pneumology and Endocrinology

Additional Organisation(s)

FAU Profilzentrum Licht.Materie.Quantentechnologien (FAU LMQ)

Involved external institutions

Universitätsklinikum Regensburg DE Germany (DE) Universitätsklinikum Münster DE Germany (DE) Klinikum rechts der Isar DE Germany (DE) Universitätsklinikum Schleswig-Holstein (UKSH) DE Germany (DE) Universität zu Lübeck DE Germany (DE)

How to cite

APA:

Fererberger, T., Buechler, C., Kandulski, A., Elger, T., Loibl, J., Schmid, S.,... Tews, H.C. (2024). Distinct metabolomic and lipidomic profiles in serum samples of patients with primary sclerosing cholangitis. Frontiers in Medicine, 11. https://doi.org/10.3389/fmed.2024.1334865

MLA:

Fererberger, Tanja, et al. "Distinct metabolomic and lipidomic profiles in serum samples of patients with primary sclerosing cholangitis." Frontiers in Medicine 11 (2024).

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