Molecularly defined sinonasal malignancies: an overview with focus on the current WHO classification and recently described provisional entities.

Skálová A, Agaimy A, Bradova M, Poorten VV, Hanna E, Guntinas-Lichius O, Franchi A, Hellquist H, Simpson RH, Lopéz F, Nuyts S, Chiesa-Estomba C, Ng SP, Homma A, Teng Y, Leivo I, Ferlito A (2024)

Publication Language: English

Publication Type: Journal article, Review article

Publication year: 2024

Journal

Virchows Archiv Springer Verlag (Germany)

Book Volume: 484

Pages Range: 885-900

Journal Issue: 6

DOI: 10.1007/s00428-024-03775-y

Abstract

Classification of tumors of the head and neck has evolved in recent decades including a widespread application of molecular testing in tumors of the sinonasal tract, salivary glands, and soft tissues with a predilection for the head and neck. The availability of new molecular techniques has allowed for the definition of multiple novel tumor types unique to head and neck sites. Moreover, an expanding spectrum of immunohistochemical markers specific to genetic alterations facilitates rapid identification of diagnostic molecular abnormalities. As such, it is currently possible for head and neck pathologists to benefit from a molecularly defined tumor classification while making diagnoses that are still based largely on histopathology and immunohistochemistry. This review covers the principal molecular alterations in sinonasal malignancies, such as alterations in DEK, AFF2, NUTM1, IDH1-2, and SWI/SNF genes in particular, that are important from a practical standpoint for diagnosis, prognosis, and prediction of response to treatment.

Authors with CRIS profile

Abbas Agaimy Lehrstuhl für Allgemeine Pathologie und Pathologische Anatomie

Involved external institutions

Central University Hospital of Asturias ES Spain (ES) University of Calgary CA Canada (CA) Katholieke Universiteit Leuven (KUL) / Catholic University of Leuven BE Belgium (BE) Donostia University Hospital / Donostia Unibertsitate Ospitalea ES Spain (ES) Austin Health AU Australia (AU) Hokkaido University Hospital / 北海道大学病院 JP Japan (JP) Emory University US United States (USA) (US) Turku University Hospital / Turun yliopistollinen keskussairaala (TYKS) FI Finland (FI) International Head and Neck Scientific Group DE Germany (DE) Univerzita Karlova v Praze / Charles University in Prague CZ Czech Republic (CZ) University of Texas MD Anderson Cancer Center US United States (USA) (US) Universitätsklinikum Jena DE Germany (DE) University of Pisa / Università di Pisa (UniPi) IT Italy (IT) University of Algarve / Universidade do Algarve PT Portugal (PT)

How to cite

APA:

Skálová, A., Agaimy, A., Bradova, M., Poorten, V.V., Hanna, E., Guntinas-Lichius, O.,... Ferlito, A. (2024). Molecularly defined sinonasal malignancies: an overview with focus on the current WHO classification and recently described provisional entities. Virchows Archiv, 484(6), 885-900. https://doi.org/10.1007/s00428-024-03775-y

MLA:

Skálová, Alena, et al. "Molecularly defined sinonasal malignancies: an overview with focus on the current WHO classification and recently described provisional entities." Virchows Archiv 484.6 (2024): 885-900.

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