Antibiotic treatment after appendectomy for acute complicated appendicitis to prevent intrabdominal abscess and wound infections

Laverde BLB, Maak M, Langheinrich M, Kersting S, Denz A, Krautz C, Weber G, Grützmann R, Brunner M (2024)

Publication Type: Journal article

Publication year: 2024

Journal

Langenbecks Archives of Surgery Springer Verlag (Germany)

Book Volume: 409

Article Number: 180

Journal Issue: 1

DOI: 10.1007/s00423-024-03367-z

Abstract

Introduction: The purpose of this analysis was to investigate the most appropriate duration of postoperative antibiotic treatment to minimize the incidence of intraabdominal abscesses and wound infections in patients with complicated appendicitis. Materials and methods: In this retrospective study, which included 396 adult patients who underwent appendectomy for complicated appendicitis between January 2010 and December 2020 at the University Hospital Erlangen, patients were classified into two groups based on the duration of their postoperative antibiotic intake: ≤ 3 postoperative days (group 1) vs. ≥ 4 postoperative days (group 2). The incidence of postoperative intraabdominal abscesses and wound infections were compared between the groups. Additionally, multivariate risk factor analysis for the occurrence of intraabdominal abscesses and wound infections was performed. Results: The two groups contained 226 and 170 patients, respectively. The incidence of postoperative intraabdominal abscesses (2% vs. 3%, p = 0.507) and wound infections (3% vs. 6%, p = 0.080) did not differ significantly between the groups. Multivariate analysis revealed that an additional cecum resection (OR 5.5 (95% CI 1.4–21.5), p = 0.014) was an independent risk factor for intraabdominal abscesses. A higher BMI (OR 5.9 (95% CI 1.2–29.2), p = 0.030) and conversion to an open procedure (OR 5.2 (95% CI 1.4–20.0), p = 0.016) were identified as independent risk factors for wound infections. Conclusion: The duration of postoperative antibiotic therapy does not appear to influence the incidence of postoperative intraabdominal abscesses and wound infections. Therefore, short-term postoperative antibiotic treatment should be preferred.

Authors with CRIS profile

Matthias Maak Medizinische Fakultät Christian Krautz Department of Surgery Georg Weber Department of Surgery Robert Grützmann Lehrstuhl für Allgemein- und Viszeralchirurgie Maximilian Brunner Lehrstuhl für Allgemein- und Viszeralchirurgie

Involved external institutions

Universität Greifswald DE Germany (DE)

How to cite

APA:

Laverde, B.L.B., Maak, M., Langheinrich, M., Kersting, S., Denz, A., Krautz, C.,... Brunner, M. (2024). Antibiotic treatment after appendectomy for acute complicated appendicitis to prevent intrabdominal abscess and wound infections. Langenbecks Archives of Surgery, 409(1). https://doi.org/10.1007/s00423-024-03367-z

MLA:

Laverde, Bruno Leonardo Bancke, et al. "Antibiotic treatment after appendectomy for acute complicated appendicitis to prevent intrabdominal abscess and wound infections." Langenbecks Archives of Surgery 409.1 (2024).

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