Influence of Magnetic Field Strength on Intravoxel Incoherent Motion Parameters in Diffusion MRI of the Calf

Bäuchle TA, Stuprich C, Loh M, Nagel AM, Uder M, Laun FB (2024)

Publication Type: Journal article

Publication year: 2024

Journal

Tomography MDPI Publishing

Book Volume: 10

Pages Range: 773-788

Journal Issue: 5

DOI: 10.3390/tomography10050059

Abstract

Background: The purpose of this study was to investigate the dependence of Intravoxel Incoherent Motion (IVIM) parameters measured in the human calf on B0. Methods: Diffusion-weighted image data of eight healthy volunteers were acquired using five b-values (0–600 s/mm²) at rest and after muscle activation at 0.55 and 7 T. The musculus gastrocnemius mediale (GM, activated) was assessed. The perfusion fraction f and diffusion coefficient D were determined using segmented fits. The dependence on field strength was assessed using Student’s t-test for paired samples and the Wilcoxon signed-rank test. A biophysical model built on the three non-exchanging compartments of muscle, venous blood, and arterial blood was used to interpret the data using literature relaxation times. Results: The measured perfusion fraction of the GM was significantly lower at 7 T, both for the baseline measurement and after muscle activation. For 0.55 and 7 T, the mean (Formula presented.) values were 7.59% and 3.63% at rest, and 14.03% and 6.92% after activation, respectively. The biophysical model estimations for the mean proton-density-weighted perfusion fraction were 3.37% and 6.50% for the non-activated and activated states, respectively. Conclusions: B0 may have a significant effect on the measured IVIM parameters. The blood relaxation times suggest that 7 T IVIM may be arterial-weighted whereas 0.55 T IVIM may exhibit an approximately equal weighting of arterial and venous blood.

Authors with CRIS profile

Christoph Stuprich Institute of Radiology Martin Loh Institute of Radiology Armin Michael Nagel Professur für metabolische und funktionelle MR-Bildgebung Michael Uder Lehrstuhl für Diagnostische Radiologie Frederik Bernd Laun Professur für quantitative MR-Bildgebung (Heisenberg-Professur)

How to cite

APA:

Bäuchle, T.A., Stuprich, C., Loh, M., Nagel, A.M., Uder, M., & Laun, F.B. (2024). Influence of Magnetic Field Strength on Intravoxel Incoherent Motion Parameters in Diffusion MRI of the Calf. Tomography, 10(5), 773-788. https://doi.org/10.3390/tomography10050059

MLA:

Bäuchle, Tamara Alice, et al. "Influence of Magnetic Field Strength on Intravoxel Incoherent Motion Parameters in Diffusion MRI of the Calf." Tomography 10.5 (2024): 773-788.

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