Mapping the HIF transcription factor in cancer by ChIP-Seq technology

Schödel J, Mole DR (2013)

Publication Type: Authored book

Publication year: 2013

Publisher: Springer New York

ISBN: 9781461476450

DOI: 10.1007/978-1-4614-7645-0_5

Abstract

Hypoxia-inducible factor (HIF) is the major transcriptional regulator mediating the cellular physiological response to reduced levels of oxygen (hypoxia). Upregulated as a consequence, both of intra-tumour hypoxia and through activation of oncogenic pathways, HIF has an important role in the pathogenesis of many cancers. However, activation of major physiological pathways in cancer upregulates pathways with both pro-and antitumorigenic actions and therefore confers a co-selection penalty. It is likely that both genetic and epigenetic factors alter the HIF-transcriptional response to favour a more tumorigenic profile. Mapping HIF transcription factor binding in cancer by ChIP-seq technology provides a framework for studying the mechanisms by which both genetic and epigenetic signatures associated with cancer may alter this HIF response.

Authors with CRIS profile

Johannes Schödel Department of Medicine 4 – Nephrology and Hypertension

Involved external institutions

University of Oxford GB United Kingdom (GB)

How to cite

APA:

Schödel, J., & Mole, D.R. (2013). Mapping the HIF transcription factor in cancer by ChIP-Seq technology. Springer New York.

MLA:

Schödel, Johannes, and David R. Mole. Mapping the HIF transcription factor in cancer by ChIP-Seq technology. Springer New York, 2013.

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