Preclinical animal model for de novo bone formation in human maxillary sinus

Schlegel KA, Rupprecht S, Petrovic L, Honert C, Srour S, von Wilmowsky C, Felszegy E, Nkenke E, Lutz R (2009)

Publication Language: English

Publication Type: Journal article

Publication year: 2009

Journal

Oral Surgery Oral Medicine Oral Pathology Oral Radiology and Endodontology Elsevier

Book Volume: 108

Pages Range: e37-e44

Journal Issue: 3

DOI: 10.1016/j.tripleo.2009.05.037

Abstract

Objectives: Up to now the effect of bone-substitute materials on de novo bone formation has been tested in a variety of preclinical animal models. We hypothesized that there is no significant difference in bone regeneration after application of autogenous bone (AB) and bone substitutes in a porcine calvarial monocortical defect model and in human maxillary sinus. Study design: Twenty-four weeks after application of ß-tricalcium phosphate (βTCP), hydroxyapatite (HA), and AB in each of 3 defects on the sculls of 6 adult pigs (N = 54) and the application in 44 sinus floor elevations (11× βTCP, 6× HA and 24× AB) in 41 patients, bone regeneration rates where compared microradiographically. Wilcoxon rank-sum test was used for statistical analysis. Results: Comparing the human with the animal specimens microradiographically, no significant difference of the mineralization rate could be found. Conclusion: The chosen porcine model is a valuable method for preclinical testing of bone-substitute materials in maxillofacial surgery. © 2009 Mosby, Inc. All rights reserved.

Authors with CRIS profile

Cornelius von Wilmowsky Department of Oral and Cranio-Maxillofacial Surgery Rainer Lutz Department of Oral and Cranio-Maxillofacial Surgery

Involved external institutions

Semmelweis University / Semmelweis Egyetem

Hungary (HU)

How to cite

APA:

Schlegel, K.A., Rupprecht, S., Petrovic, L., Honert, C., Srour, S., von Wilmowsky, C.,... Lutz, R. (2009). Preclinical animal model for de novo bone formation in human maxillary sinus. Oral Surgery Oral Medicine Oral Pathology Oral Radiology and Endodontology, 108(3), e37-e44. https://doi.org/10.1016/j.tripleo.2009.05.037

MLA:

Schlegel, Karl Andreas, et al. "Preclinical animal model for de novo bone formation in human maxillary sinus." Oral Surgery Oral Medicine Oral Pathology Oral Radiology and Endodontology 108.3 (2009): e37-e44.

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