Osseointegration of SLActive implants in diabetic pigs

Schlegel KA, Prechtl C, Möst T, Seidl C, Lutz R, von Wilmowsky C (2013)

Publication Type: Journal article

Publication year: 2013

Journal

Clinical Oral Implants Research Wiley-Blackwell

Book Volume: 24

Pages Range: 128-134

Journal Issue: 2

DOI: 10.1111/j.1600-0501.2011.02380.x

Abstract

Objectives: Diabetes mellitus is currently classified as a relative contraindication for implant treatment because of microangiopathies with the consequence of impaired bone regeneration and higher rates of implant failure. The study aim was to investigate peri-implant bone formation in a diabetic animal model in comparison to healthy animals and to evaluate the differences between conventional (SLA^®) and modified (SLActive^®) titanium implant surfaces on osseointegration. Material and methods: Each six implants were placed in the calvaria of 11 diabetic and 4 healthy domestic pigs. At 30 and 90 days after implant placement, the bone-to-implant contact (BIC) and bone density (BD) were appraised. Additionally, the expression of the bone-matrix proteins collagen type I and osteocalcin was evaluated at both points in time by using immunohistochemical staining methods. Results: Overall, BIC was reduced in the diabetic group at 30 and 90 days. After 90 days, the SLActive^® implants showed significantly higher BICs compared with the SLA^® implants in diabetic animals. Peri-implant BD was higher in the SLActive^® group at 30 and 90 days in healthy and diabetic animals. Collagen type I protein expression was higher using SLA^® implants in diabetic pigs at 30 days. Values for osteocalcin expression were not consistent. Conclusions: The results indicate the negative effect of untreated diabetes mellitus on early osseointegration of dental implants. The modified SLA^® surface (SLActive^®) elicited an accelerated osseointegration of dental implants, suggesting that a better prognosis for implant treatment of diabetic patients is possible. © 2011 John Wiley & Sons A/S.

Authors with CRIS profile

Tobias Möst Department of Oral and Cranio-Maxillofacial Surgery Rainer Lutz Department of Oral and Cranio-Maxillofacial Surgery Cornelius von Wilmowsky Department of Oral and Cranio-Maxillofacial Surgery

How to cite

APA:

Schlegel, K.A., Prechtl, C., Möst, T., Seidl, C., Lutz, R., & von Wilmowsky, C. (2013). Osseointegration of SLActive implants in diabetic pigs. Clinical Oral Implants Research, 24(2), 128-134. https://doi.org/10.1111/j.1600-0501.2011.02380.x

MLA:

Schlegel, Karl Andreas, et al. "Osseointegration of SLActive implants in diabetic pigs." Clinical Oral Implants Research 24.2 (2013): 128-134.

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