Comparison of the prognostic value of lymph node yield, lymph node ratio, and number of lymph node metastases in patients with oral squamous cell carcinoma

Struckmeier AK, Buchbender M, Lutz R, Agaimy A, Kesting MR (2024)

Publication Type: Journal article

Publication year: 2024

Journal

Head and Neck-Journal For the Sciences and Specialties of the Head and Neck Wiley-Blackwell

Book Volume: 46

Pages Range: 1083-1093

Journal Issue: 5

DOI: 10.1002/hed.27748

Abstract

Background: The aim of this study was to assess the prognostic significance of lymph node yield (LNY), lymph node ratio (LNR), and the number of lymph node metastases (LNMs) in patients affected by oral squamous cell carcinoma (OSCC). Methods: The study included patients who underwent surgical treatment for primary OSCC. Receiver operating characteristic curves were generated to determine the optimal threshold values. Kaplan–Meier curves were employed, along with the log-rank test, for the analysis of survival. To compare the performance in terms of model fit, we computed Akaike's information criterion (AIC). Results: This study enrolled 429 patients. Prognostic thresholds were determined at 22 for LNY, 6.6% for LNR, and 3 for the number of LNMs. The log-rank test revealed a significant improvement in both overall survival and progression-free survival for patients with a LNR of ≤6.6% or a number of LNMs of ≤3 (p < 0.05). Interestingly, LNY did not demonstrate prognostic significance. The AIC analyses indicated that the number of LNMs is a superior prognostic indicator compared to LNY and LNR. Conclusions: Incorporating LNR or the number of LNMs into the TNM classification has the potential to improve the prognostic value, as in other types of cancers. Particularly, the inclusion of the number of LNMs should be contemplated for future N staging.

Authors with CRIS profile

Ann-Kristin Struckmeier Department of Oral and Cranio-Maxillofacial Surgery Mayte Buchbender Department of Oral and Cranio-Maxillofacial Surgery Rainer Lutz Department of Oral and Cranio-Maxillofacial Surgery Abbas Agaimy Lehrstuhl für Allgemeine Pathologie und Pathologische Anatomie Marco Rainer Kesting Lehrstuhl für Zahnmedizin, insbesondere Mund-, Kiefer-, und Gesichtschirurgie

Additional Organisation(s)

Tumorzentrum der Universität Erlangen-Nürnberg

How to cite

APA:

Struckmeier, A.-K., Buchbender, M., Lutz, R., Agaimy, A., & Kesting, M.R. (2024). Comparison of the prognostic value of lymph node yield, lymph node ratio, and number of lymph node metastases in patients with oral squamous cell carcinoma. Head and Neck-Journal For the Sciences and Specialties of the Head and Neck, 46(5), 1083-1093. https://doi.org/10.1002/hed.27748

MLA:

Struckmeier, Ann-Kristin, et al. "Comparison of the prognostic value of lymph node yield, lymph node ratio, and number of lymph node metastases in patients with oral squamous cell carcinoma." Head and Neck-Journal For the Sciences and Specialties of the Head and Neck 46.5 (2024): 1083-1093.

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