Velocity-compensated intravoxel incoherent motion of the human calf muscle

Stuprich C, Loh M, Nemerth J, Nagel AM, Uder M, Laun FB (2024)

Publication Language: English

Publication Type: Journal article

Publication year: 2024

Journal

Magnetic Resonance in Medicine Wiley

Book Volume: 92

Pages Range: 543-555

Journal Issue: 2

DOI: 10.1002/mrm.30059

Abstract

Purpose: To determine whether intravoxel incoherent motion (IVIM) describes the blood perfusion in muscles better, assuming pseudo diffusion (Bihan Model 1) or ballistic motion (Bihan Model 2). Methods: IVIM parameters were measured in 18 healthy subjects with three different diffusion gradient time profiles (bipolar with two diffusion times and one with velocity compensation) and 17 b-values (0–600 s/mm²) at rest and after muscle activation. The diffusion coefficient, perfusion fraction, and pseudo-diffusion coefficient were estimated with a segmented fit in the gastrocnemius medialis (GM) and tibialis anterior (TA) muscles. Results: Velocity-compensated gradients resulted in a decreased perfusion fraction (6.9% ± 1.4% vs. 4.4% ± 1.3% in the GM after activation) and pseudo-diffusion coefficient (0.069 ± 0.046 mm²/s vs. 0.014 ± 0.006 in the GM after activation) compared to the bipolar gradients with the longer diffusion encoding time. Increased diffusion coefficients, perfusion fractions, and pseudo-diffusion coefficients were observed in the GM after activation for all gradient profiles. However, the increase was significantly smaller for the velocity-compensated gradients. A diffusion time dependence was found for the pseudo-diffusion coefficient in the activated muscle. Conclusion: Velocity-compensated diffusion gradients significantly suppress the IVIM effect in the calf muscle, indicating that the ballistic limit is mostly reached, which is supported by the time dependence of the pseudo-diffusion coefficient.

Authors with CRIS profile

Christoph Stuprich Institute of Radiology Martin Loh Institute of Radiology Johannes Nemerth Lehrstuhl für Diagnostische Radiologie Armin Michael Nagel Professur für metabolische und funktionelle MR-Bildgebung Michael Uder Lehrstuhl für Diagnostische Radiologie Frederik Bernd Laun Professur für quantitative MR-Bildgebung (Heisenberg-Professur)

How to cite

APA:

Stuprich, C., Loh, M., Nemerth, J., Nagel, A.M., Uder, M., & Laun, F.B. (2024). Velocity-compensated intravoxel incoherent motion of the human calf muscle. Magnetic Resonance in Medicine, 92(2), 543-555. https://doi.org/10.1002/mrm.30059

MLA:

Stuprich, Christoph, et al. "Velocity-compensated intravoxel incoherent motion of the human calf muscle." Magnetic Resonance in Medicine 92.2 (2024): 543-555.

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