Statement of the Uterus Commission of the Gynecological Oncology Working Group (AGO) on Neoadjuvant Chemotherapy Prior to Definitive Radiochemotherapy in Patients with Locally Advanced Cervical Cancer
Tempfer C, Fehm T, Vordermark D, Marnitz-Schulze S, Beckmann M, Denschlag D, Brucker S, Wallwiener M, Eichbaum M, Ataseven B, Hillemanns P (2024)
Publication Type: Journal article
Publication year: 2024
Journal
DOI: 10.1055/a-2279-3163
Abstract
The presentation of the results of the prospective randomized international multicenter GCIG INTERLACE trial at the 2023 congress of the European Society of Medical Oncology (ESMO) is likely to change the therapy for locally advanced cervical cancer. In the GCIG INTERLACE trial, six cycles of neoadjuvant chemotherapy administered weekly and consisting of carboplatin AUC2 and paclitaxel 80 mg/m 2followed by definitive radiochemotherapy with pelvic radiotherapy (40-50.4 Gray) and cisplatin (40 mg/m 2once a week for 5 weeks) and brachytherapy (total dose EQD2 at least 78 Gy at point A) (experimental arm) were compared with definitive radiochemotherapy alone (standard arm) in patients with locally advanced cervical cancer (Fédération Internationale de Gynécologie et d Obstétrique [FIGO] 2008 stage IB1/node positive, IB2, II, IIIB and IVA) and was found to be significantly superior with significantly longer recurrence-free survival (hazard ratio [HR] 0.65; 95% confidence interval [CI] 0.64-0.91; p = 0.013) and significantly longer overall survival rates (HR 0.61; 95% CI: 0.40-0.91; p = 0.04) after 5 years follow-up. After considering the results of the GCIG INTERLACE trial published at the congress, the Uterus Commission of the AGO is of the opinion that neoadjuvant chemotherapy with carboplatin AUC2 and paclitaxel 80 mg/m 2d1, q7, x6 may be offered to patients with locally advanced cervical cancer (FIGO stage IB1/node positive, IB2, II, IIIB and IVA) in addition to the current standard therapy after the patient has been informed about the risks, with the decision taken on a case-by-case basis. However, before this approach can be discussed at guideline level or defined as the new therapy standard, it will be necessary to wait until the data from the full publication are available.
Authors with CRIS profile
Involved external institutions
Universitätsklinikum Halle (Saale)
Germany (DE)
Radioonkologie im Vosspalais
Germany (DE)
HELIOS Kliniken
Germany (DE)
Medizinische Hochschule Hannover (MHH) / Hannover Medical School
Germany (DE)
Hochtaunus-Kliniken
Germany (DE)
Universitätsklinikum Düsseldorf
Germany (DE)
Universität Bielefeld
Germany (DE)
Ruhr-Universität Bochum (RUB)
Germany (DE)
Universitätsklinikum Tübingen
Germany (DE)
Germany (DE)
Radioonkologie im Vosspalais
Germany (DE)
HELIOS Kliniken
Germany (DE)
Medizinische Hochschule Hannover (MHH) / Hannover Medical School
Germany (DE)
Hochtaunus-Kliniken
Germany (DE)
Universitätsklinikum Düsseldorf
Germany (DE)
Universität Bielefeld
Germany (DE)
Ruhr-Universität Bochum (RUB)
Germany (DE)
Universitätsklinikum Tübingen
Germany (DE)
How to cite
APA:
Tempfer, C., Fehm, T., Vordermark, D., Marnitz-Schulze, S., Beckmann, M., Denschlag, D.,... Hillemanns, P. (2024). Statement of the Uterus Commission of the Gynecological Oncology Working Group (AGO) on Neoadjuvant Chemotherapy Prior to Definitive Radiochemotherapy in Patients with Locally Advanced Cervical Cancer. Geburtshilfe und Frauenheilkunde. https://doi.org/10.1055/a-2279-3163
MLA:
Tempfer, Clemens, et al. "Statement of the Uterus Commission of the Gynecological Oncology Working Group (AGO) on Neoadjuvant Chemotherapy Prior to Definitive Radiochemotherapy in Patients with Locally Advanced Cervical Cancer." Geburtshilfe und Frauenheilkunde (2024).
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