Denz A, Hahn V, Weber K, Weber G, Grützmann R, Krautz C, Brunner M (2024)
Publication Language: English
Publication Type: Journal article
Publication year: 2024
Book Volume: 409
Article Number: 121
Journal Issue: 1
DOI: 10.1007/s00423-024-03311-1
Purpose: The optimal management of colorectal lung metastases (CRLM) is still controversial. The aim of this study was to compare surgical and non-surgical treatment for CRLM regarding the prognostic outcome. Methods: This retrospective single-center cohort study included 418 patients, who were treated from January 2000 to December 2018 at a German University Hospital due to their colorectal carcinoma and had synchronous or metachronous lung metastases. Patients were stratified according the treatment of the CRLM into two groups: surgical resection of CRLM versus no surgical resection of CRLM. The survival from the time of diagnosis of lung metastasis was compared between the groups. Results: Two- and 5-year overall survival (OS) from the time of diagnosis of lung metastasis was 78.2% and 54.6%, respectively, in our cohort. Patients undergoing pulmonary metastasectomy showed a significantly better 2- and 5-year survival compared to patients with non-surgical treatment (2-year OS: 98.1% vs. 67.9%; 5-year OS: 81.2% vs. 28.8%; p < 0.001). Multivariate Cox regression revealed the surgical treatment (HR 4.51 (95% CI = 2.33–8.75, p < 0.001) and the absence of other metastases (HR 1.79 (95% CI = 1.05–3.04), p = 0.032) as independent prognostic factors in patients with CRLM. Conclusion: Our data suggest that patients with CRLM, who qualify for surgery, benefit from surgical treatment. Randomized controlled trials are needed to confirm our findings. Clinical trial registry number: The work has been retrospectively registrated at the German Clinical Trial Registry (DRKS00032938).
APA:
Denz, A., Hahn, V., Weber, K., Weber, G., Grützmann, R., Krautz, C., & Brunner, M. (2024). Survival outcome following surgical versus non-surgical treatment of colorectal lung metastasis—a retrospective cohort study. Langenbecks Archives of Surgery, 409(1). https://doi.org/10.1007/s00423-024-03311-1
MLA:
Denz, Axel, et al. "Survival outcome following surgical versus non-surgical treatment of colorectal lung metastasis—a retrospective cohort study." Langenbecks Archives of Surgery 409.1 (2024).
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