Kalinichenko L, Kornhuber J, Sinning S, Haase J, Müller CP (2024)
Publication Type: Journal article, Review article
Publication year: 2024
Book Volume: 15
Pages Range: 1298-1320
Journal Issue: 7
DOI: 10.1021/acschemneuro.3c00823
Serotonin (5-HT) is a vital modulatory neurotransmitter responsible for regulating most behaviors in the brain. An inefficient 5-HT synaptic function is often linked to various mental disorders. Primarily, membrane proteins controlling the expression and activity of 5-HT synthesis, storage, release, receptor activation, and inactivation are critical to 5-HT signaling in synaptic and extra-synaptic sites. Moreover, these signals represent information transmission across membranes. Although the lipid membrane environment is often viewed as fairly stable, emerging research suggests significant functional lipid-protein interactions with many synaptic 5-HT proteins. These protein-lipid interactions extend to almost all the primary lipid classes that form the plasma membrane. Collectively, these lipid classes and lipid-protein interactions affect 5-HT synaptic efficacy at the synapse. The highly dynamic lipid composition of synaptic membranes suggests that these lipids and their interactions with proteins may contribute to the plasticity of the 5-HT synapse. Therefore, this broader protein-lipid model of the 5-HT synapse necessitates a reconsideration of 5-HT’s role in various associated mental disorders.
APA:
Kalinichenko, L., Kornhuber, J., Sinning, S., Haase, J., & Müller, C.P. (2024). Serotonin Signaling through Lipid Membranes. ACS Chemical Neuroscience, 15(7), 1298-1320. https://doi.org/10.1021/acschemneuro.3c00823
MLA:
Kalinichenko, Liubov, et al. "Serotonin Signaling through Lipid Membranes." ACS Chemical Neuroscience 15.7 (2024): 1298-1320.
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