Results of patch testing with five fragrance materials hitherto not tested: A dose-finding study in the clinical population
Sukakul T, Uter W, Gonçalo M, Huggard J, Ljubojević Hadžavdić S, Schuttelaar ML, Svedman C, Vey M, Isaksson M, Niklasson B, Rustemeyer T, Bruze M (2024)
Publication Type: Journal article
Publication year: 2024
Journal
DOI: 10.1111/cod.14525
Abstract
Background: Quantitative risk assessment (QRA) for skin sensitization is used to derive safe use levels of sensitising fragrance ingredients in products. Post-marketing surveillance of the prevalence of contact allergy to these ingredients provides relevant data to help evaluate the performance of these measures. Objectives: To determine a suitable patch test concentration for five fragrance materials that had hitherto not been tested on a regular basis. These concentrations are then to be used in a surveillance study with patch testing consecutive patients over an extended monitoring period. Materials and Methods: Furaneol, CAS.3658-77-3; trans-2-hexenal, CAS.6728-26-3; 4,8-dimethyl-4,9-decadienal, CAS.71077-31-1; longifolene, CAS.475-20-7; benzaldehyde, CAS.10052-7, were patch tested with other fragrance allergens in four clinics. Patch testing was conducted in three rounds, starting with the lowest concentrations of the five ingredients. The doses were increased in the subsequent rounds if no late-appearing positive reactions and virtually no irritant reactions were reported. Results: Overall, 373 patients were tested. No positive allergic reaction was reported to the five ingredients. Patch test results of other fragrance allergens are reported. Conclusions: The highest test concentrations are each considered safe for patch testing consecutive patients. Further surveillance based on these preparations will evaluate the hypothesis that QRA-driven consumer product levels of these fragrances can prevent sensitization.
Authors with CRIS profile
Involved external institutions
Lund University / Lunds universitet
Sweden (SE)
Centro Hospitalar e Universitário de Coimbra (CHUC)
Portugal (PT)
The Huggard Consulting Group
Luxembourg (LU)
Zagreb University Hospital Centre / Klinički bolnički centar Zagreb (KBC)
Croatia (HR)
University Medical Center Groningen (UMCG) / Universitair Medisch Centrum Groningen
Netherlands (NL)
Chemotechnique Diagnostics
Sweden (SE)
Amsterdam University Medical Centers (Amsterdam UMC) / Amsterdam Universitair Medische Centra
Netherlands (NL)
Sweden (SE)
Centro Hospitalar e Universitário de Coimbra (CHUC)
Portugal (PT)
The Huggard Consulting Group
Luxembourg (LU)
Zagreb University Hospital Centre / Klinički bolnički centar Zagreb (KBC)
Croatia (HR)
University Medical Center Groningen (UMCG) / Universitair Medisch Centrum Groningen
Netherlands (NL)
Chemotechnique Diagnostics
Sweden (SE)
Amsterdam University Medical Centers (Amsterdam UMC) / Amsterdam Universitair Medische Centra
Netherlands (NL)
How to cite
APA:
Sukakul, T., Uter, W., Gonçalo, M., Huggard, J., Ljubojević Hadžavdić, S., Schuttelaar, M.L.,... Bruze, M. (2024). Results of patch testing with five fragrance materials hitherto not tested: A dose-finding study in the clinical population. Contact Dermatitis. https://doi.org/10.1111/cod.14525
MLA:
Sukakul, Thanisorn, et al. "Results of patch testing with five fragrance materials hitherto not tested: A dose-finding study in the clinical population." Contact Dermatitis (2024).
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