Toward designing human intervention studies to prevent osteoarthritis after knee injury: A report from an interdisciplinary OARSI 2023 workshop

Whittaker JL, Kalsoum R, Bilzon J, Conaghan PG, Crossley K, Dodge GR, Getgood A, Li X, Losina E, Mason DJ, Pietrosimone B, Risberg MA, Roemer F, Felson D, Culvenor AG, Meuffels D, Gerwin N, Simon LS, Lohmander LS, Englund M, Watt FE (2024)

Publication Type: Journal article

Publication year: 2024

Journal

Book Volume: 6

Article Number: 100449

Journal Issue: 2

DOI: 10.1016/j.ocarto.2024.100449

Abstract

Objective: The global impact of osteoarthritis is growing. Currently no disease modifying osteoarthritis drugs/therapies exist, increasing the need for preventative strategies. Knee injuries have a high prevalence, distinct onset, and strong independent association with post-traumatic osteoarthritis (PTOA). Numerous groups are embarking upon research that will culminate in clinical trials to assess the effect of interventions to prevent knee PTOA despite challenges and lack of consensus about trial design in this population. Our objectives were to improve awareness of knee PTOA prevention trial design and discuss state-of-the art methods to address the unique opportunities and challenges of these studies. Design: An international interdisciplinary group developed a workshop, hosted at the 2023 Osteoarthritis Research Society International Congress. Here we summarize the workshop content and outputs, with the goal of moving the field of PTOA prevention trial design forward. Results: Workshop highlights included discussions about target population (considering risk, homogeneity, and possibility of modifying osteoarthritis outcome); target treatment (considering delivery, timing, feasibility and effectiveness); comparators (usual care, placebo), and primary symptomatic outcomes considering surrogates and the importance of knee function and symptoms other than pain to this population. Conclusions: Opportunities to test multimodal PTOA prevention interventions across preclinical models and clinical trials exist. As improving symptomatic outcomes aligns with patient and regulator priorities, co-primary symptomatic (single or aggregate/multidimensional outcome considering function and symptoms beyond pain) and structural/physiological outcomes may be appropriate for these trials. To ensure PTOA prevention trials are relevant and acceptable to all stakeholders, future research should address critical knowledge gaps and challenges.

Authors with CRIS profile

Involved external institutions

Lund University / Lunds universitet Sweden (SE) Imperial College London / The Imperial College of Science, Technology and Medicine United Kingdom (GB) University of British Columbia Canada (CA) University of Bath United Kingdom (GB) University of Leeds United Kingdom (GB) La Trobe University Australia (AU) Perelman School of Medicine University of Pennsylvania United States (USA) (US) Western University Canada (CA) Cleveland Clinic United States (USA) (US) Brigham and Women's Hospital (BWH) United States (USA) (US) Cardiff University United Kingdom (GB) University of North Carolina at Chapel Hill United States (USA) (US) Norwegian School of Sport Sciences / Norges idrettshøgskole Norway (NO) Boston University United States (USA) (US) Erasmus University Medical Center (MC) Netherlands (NL) Novartis AG Switzerland (CH) SDG LLC United States (USA) (US)

How to cite

APA:

Whittaker, J.L., Kalsoum, R., Bilzon, J., Conaghan, P.G., Crossley, K., Dodge, G.R.,... Watt, F.E. (2024). Toward designing human intervention studies to prevent osteoarthritis after knee injury: A report from an interdisciplinary OARSI 2023 workshop. Osteoarthritis and Cartilage Open, 6(2). https://doi.org/10.1016/j.ocarto.2024.100449

MLA:

Whittaker, Jackie L., et al. "Toward designing human intervention studies to prevent osteoarthritis after knee injury: A report from an interdisciplinary OARSI 2023 workshop." Osteoarthritis and Cartilage Open 6.2 (2024).

BibTeX: Download