Huang M, Fasching P, Haiderali A, Xue W, Pan W, Karantza V, Yang F, Truscott J, Xin Y, O'Shaughnessy J (2024)
Publication Language: English
Publication Type: Journal article, Review article
Publication year: 2024
Book Volume: 20
Pages Range: 335-348
Journal Issue: 6
Aim: This study evaluated event-free survival (EFS) as a surrogate outcome for overall survival (OS) in neoadjuvant therapy for early-stage triple-negative breast cancer (eTNBC). Methods: Meta-regression analyses based on a targeted literature review were used to evaluate the individual- and trial-level associations between EFS and OS. Results: In the individual-level analyses, 3-year EFS was a significant predictor of 5-year OS (p < 0.01; coefficient of determinations [R2]: 0.82 [95% CI: 0.68-0.91]). Additionally, there was a statistically significant association between the treatment effect on EFS and OS at the trial level (p < 0.001; R2: 0.64 [95% CI: 0.45-0.82]). Conclusion: This study demonstrates significant associations between EFS and OS and suggests that EFS is a valid surrogate for OS following neoadjuvant therapy for eTNBC.
APA:
Huang, M., Fasching, P., Haiderali, A., Xue, W., Pan, W., Karantza, V.,... O'Shaughnessy, J. (2024). Association between event-free survival and overall survival in early-stage triple-negative breast cancer. Future Oncology, 20(6), 335-348. https://doi.org/10.2217/fon-2023-0315
MLA:
Huang, Min, et al. "Association between event-free survival and overall survival in early-stage triple-negative breast cancer." Future Oncology 20.6 (2024): 335-348.
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