Heiland DH, Staszewski O, Hirsch M, Masalha W, Franco P, Grauvogel J, Capper D, Schrimpf D, Urbach H, Weyerbrock A (2016)
Publication Type: Journal article
Publication year: 2016
Book Volume: 75
Pages Range: 358-365
Journal Issue: 4
DOI: 10.1093/jnen/nlw007
Dysembryoplastic neuroepithelial tumors (DNET) are considered to be rare, benign, and associated with chronic epilepsy. We present the case of a 28-year-old man with a history of epilepsy since age 12. Surgery of an occipital cortical lesion in 2009 revealed a DNET. Five years later, a recurrent tumor at the edge of the resection cavity was removed, and the tissue underwent an intensive diagnostic workup. The first tumor was unequivocally characterized as a DNET, but neuropathological diagnostics of the recurrent tumor revealed a glioblastoma. After 6 months, another recurrent tumor was detected next to the location of the original tumor, and this was also resected. An Illumina 450 K beadchip methylation array was performed to characterize all of the tumors. The methylation profile of these tumors significantly differed from other glioblastoma and epilepsy-associated tumor profiles and revealed a DNET-like methylation profile. Thus, molecular characterization of these recurrent tumors suggests malignant transformation of a previously benign DNET. We found increased copy number changes in the recurrent DNET tumors after malignant transformation. Modern high-throughput analysis adds essential molecular information in addition to standard histopathology for proper identification of rare brain tumors that present with an unusual clinical course.
APA:
Heiland, D.H., Staszewski, O., Hirsch, M., Masalha, W., Franco, P., Grauvogel, J.,... Weyerbrock, A. (2016). Malignant transformation of a dysembryoplastic neuroepithelial tumor (DNET) characterized by genome-wide methylation analysis. Journal of Neuropathology and Experimental Neurology, 75(4), 358-365. https://doi.org/10.1093/jnen/nlw007
MLA:
Heiland, Dieter Henrik, et al. "Malignant transformation of a dysembryoplastic neuroepithelial tumor (DNET) characterized by genome-wide methylation analysis." Journal of Neuropathology and Experimental Neurology 75.4 (2016): 358-365.
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