Glioma vessel abnormality quantification using time-of-flight MR angiography

Strumia M, Reichardt W, Staszewski O, Heiland DH, Weyerbrock A, Mader I, Bock M (2016)

Publication Type: Journal article

Publication year: 2016

Journal

Magnetic Resonance Materials in Physics Biology and Medicine Springer Verlag (Germany)

Book Volume: 29

Pages Range: 765-775

Journal Issue: 5

DOI: 10.1007/s10334-016-0558-z

Abstract

Objectives: To differentiate between abnormal tumor vessels and regular brain vasculature using new quantitative measures in time-of-flight (TOF) MR angiography (MRA) data. Materials and methods: In this work time-of-flight (TOF) MR angiography data are acquired in 11 glioma patients to quantify vessel abnormality. Brain vessels are first segmented with a new algorithm, efficient monte-carlo image-analysis for the location of vascular entity (EMILOVE), and are then characterized in three brain regions: tumor, normal-appearing contralateral brain, and the total brain volume without the tumor. For characterization local vessel orientation angles and the dot product between local orientation vectors are calculated and averaged in the 3 regions. Additionally, correlation with histological and genetic markers is performed. Results: Both the local vessel orientation angles and the dot product show a statistically significant difference (p < 0.005) between tumor vessels and normal brain vasculature. Furthermore, the connection to both histology and the gene expression of the tumor can be found—here, the measures were compared to the proliferation marker Ki-67 [MIB] and genome-wide expression analysis. The results in a subgroup indicate that the dot product measure may be correlated with activated genetic pathways. Conclusion: It is possible to define a measure of vessel abnormality based on local vessel orientation angles which can differentiate between normal brain vasculature and glioblastoma vessels.

Authors with CRIS profile

Dieter Henrik Heiland

Involved external institutions

Deutsches Krebsforschungszentrum (DKFZ) DE Germany (DE) Universitätsklinikum Freiburg DE Germany (DE)

How to cite

APA:

Strumia, M., Reichardt, W., Staszewski, O., Heiland, D.H., Weyerbrock, A., Mader, I., & Bock, M. (2016). Glioma vessel abnormality quantification using time-of-flight MR angiography. Magnetic Resonance Materials in Physics Biology and Medicine, 29(5), 765-775. https://doi.org/10.1007/s10334-016-0558-z

MLA:

Strumia, Maddalena, et al. "Glioma vessel abnormality quantification using time-of-flight MR angiography." Magnetic Resonance Materials in Physics Biology and Medicine 29.5 (2016): 765-775.

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