Tumor-host cell interaction in the microenvironment: new target points for treatment? Tumor-Wirtszellen-Interaktion im Mikromilieu: neue Angriffspunkte für die Therapie?
Sevenich L, Heiland DH (2024)
Publication Type: Journal article, Review article
Publication year: 2024
Journal
Book Volume: 95
Pages Range: 104-110
Journal Issue: 2
DOI: 10.1007/s00115-023-01604-2
Abstract
Background: Primary brain tumors and metastases in the central nervous system (CNS) are characterized by their unique microenvironment, which interacts with neuronal structures and influences structural and adaptive immunity. Objective: How significant are various tumor-host interactions from a prognostic and therapeutic perspective? Material and method: A literature search was carried out for relevant articles on the topic: microenvironment glioblastoma or metastasis through PubMed and Medline. Results: Modern high-throughput methods, such as spatial and single-cell resolution molecular characterization of tumors and their microenvironment enable a detailed mapping of changes and adaptation of individual cells within the microenvironment of tumors; however, treatment approaches based on altered tumor-host cell interactions, such as immune modeling, cell-based treatment methods or checkpoint inhibition have so far not shown any significant advantages for survival. Conclusion: A deeper understanding of the complex immune landscape and the microenvironment of metastases of the CNS and intracerebral tumors is essential to optimize future treatment strategies.
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Germany (DE)How to cite
APA:
Sevenich, L., & Heiland, D.H. (2024). Tumor-host cell interaction in the microenvironment: new target points for treatment? Tumor-Wirtszellen-Interaktion im Mikromilieu: neue Angriffspunkte für die Therapie? Der Nervenarzt, 95(2), 104-110. https://doi.org/10.1007/s00115-023-01604-2
MLA:
Sevenich, Lisa, and Dieter Henrik Heiland. "Tumor-host cell interaction in the microenvironment: new target points for treatment? Tumor-Wirtszellen-Interaktion im Mikromilieu: neue Angriffspunkte für die Therapie?" Der Nervenarzt 95.2 (2024): 104-110.
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