High-alert medications for hospitalised paediatric patients - a two-step survey among paediatric clinical expert pharmacists in Germany.
Schilling S, Koeck JA, Kontny U, Orlikowsky T, Erdmann H, Eisert A (2022)
Publication Type: Journal article
Publication year: 2022
Journal
Book Volume: 77
Pages Range: 207-215
Journal Issue: 6
Abstract
Paediatric patients are more vulnerable to be harmed by medication errors compared to adults due to pharmacokinetic and pharmacodynamic changes in their development, individual dosing calculations, and manipulation of ready to-use products intended for adult patients. According to the Institute of Safe Medication Practices, there are some "drugs that bear a heightened risk of causing significant patient harm when they are used in error"; these drugs are called high-alert medications (HAM). The two-step survey among paediatric clinical expert pharmacists presented here aimed to compile a nation-wide HAM list. To provide detailed guidance, this survey followed a drugbased approach, resulting in specific potential drug related problems (DRPs) and associated recommendations for prevention. In contrast to this approach, in the first round of the survey two drug classes were included that both were rated as HAM (i.e.chemotherapy and parenteral nutrition). Twenty single drugs were identified as HAM, 65% of which were cardiovascular or neurological drugs. The paediatric expert pharmacists mentioned in total 216 potential DRPs; in particular, they identified potential administration-related problems (28% of all DRPs), dosing-related problems (26%), and drug-choice-related problems (18%, e.g.drug confusion and drug monitoring). Moreover, they suggested 275 potential interventions to address these DRPs. Two thirds of all interventions dealt with the preparation by the hospital pharmacy, standardisation of processes (e.g.labelling), and education or training. In conclusion, this survey provided a German paediatric high-alert medication list from a paediatric pharmacist point of view. Moreover, the experts mentioned for the first time specific potential DRPs and associated interventions to guide a local multidisciplinary approach for preventing medication-related harm in children.
Involved external institutions
Germany (DE)How to cite
APA:
Schilling, S., Koeck, J.A., Kontny, U., Orlikowsky, T., Erdmann, H., & Eisert, A. (2022). High-alert medications for hospitalised paediatric patients - a two-step survey among paediatric clinical expert pharmacists in Germany. Pharmazie, 77(6), 207-215. https://dx.doi.org/10.1691/ph.2022.12025
MLA:
Schilling, S., et al. "High-alert medications for hospitalised paediatric patients - a two-step survey among paediatric clinical expert pharmacists in Germany." Pharmazie 77.6 (2022): 207-215.
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