Lymphadenopathy in a novel mouse model of Bartonella-induced cat scratch disease results from lymphocyte immigration and proliferation and is regulated by interferon-α/β
Kunz S, Oberle K, Sander A, Bogdan C, Schleicher U (2008)
Publication Type: Journal article
Publication year: 2008
Journal
Book Volume: 172
Pages Range: 1005-1018
Journal Issue: 4
DOI: 10.2353/ajpath.2008.070591
Abstract
In immunocompetent humans, cat scratch disease (CSD) is elicited by the Gram-negative bacterium Bartonella henselae and is characterized by a benign regional lymphadenopathy, the pathogenesis of which is poorly understood. Here, we describe a novel mouse model of Bartonella-induced CSD-like disease that allowed us to investigate the mechanisms leading to lymphadenopathy in vivo. In wild-type mice, a subcutaneous inoculation of either viable or inactivated B. henselae led to a strong swelling of the draining lymph node, which was long-lasting despite the rapid elimination of the bacteria. Carboxyfluoresceinand bromodesoxyuridine-labeling experiments showed that lymph node enlargement resulted from modified immigration and enhanced proliferation of lymphocytes, preferentially of B cells. A comparative analysis of B. henselae and the rodent pathogen B. grahamii in wild-type versus interferon-α/ β-receptor I chain-deficient mice revealed that interferon-α/β is not only differentially induced by these two Bartonella species but also exerts an inhibitory effect on the development of lymphadenopathy both in vitro and in vivo. These data demonstrate that the lymphadenopathy of human CSD can be reproduced and studied in a mouse model and provide the first insights into the underlying immunological mechanisms. Copyright © American Society for Investigative Pathology.
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APA:
Kunz, S., Oberle, K., Sander, A., Bogdan, C., & Schleicher, U. (2008). Lymphadenopathy in a novel mouse model of Bartonella-induced cat scratch disease results from lymphocyte immigration and proliferation and is regulated by interferon-α/β. American Journal of Pathology, 172(4), 1005-1018. https://dx.doi.org/10.2353/ajpath.2008.070591
MLA:
Kunz, Stefanie, et al. "Lymphadenopathy in a novel mouse model of Bartonella-induced cat scratch disease results from lymphocyte immigration and proliferation and is regulated by interferon-α/β." American Journal of Pathology 172.4 (2008): 1005-1018.
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