Long interspersed nuclear elements safeguard neural progenitors from precocious differentiation

Toda T, Bedrosian TA, Schafer ST, Cuoco MS, Linker SB, Ghassemzadeh S, Mitchell L, Whiteley JT, Novaresi N, McDonald AH, Gallina IS, Yoon H, Hester ME, Pena M, Lim C, Suljic E, AlFatah Mansour A, Boulard M, Parylak SL, Gage FH (2024)

Publication Type: Journal article

Publication year: 2024

Journal

Cell Reports Elsevier (Cell Press)

Book Volume: 43

Article Number: 113774

Journal Issue: 2

DOI: 10.1016/j.celrep.2024.113774

Abstract

Long interspersed nuclear element-1 (L1 or LINE-1) is a highly abundant mobile genetic element in both humans and mice, comprising almost 20% of each genome. L1s are silenced by several mechanisms, as their uncontrolled expression has the potential to induce genomic instability. However, L1s are paradoxically expressed at high levels in differentiating neural progenitor cells. Using in vitro and in vivo techniques to modulate L1 expression, we report that L1s play a critical role in both human and mouse brain development by regulating the rate of neural differentiation in a reverse-transcription-independent manner.

Involved external institutions

Salk Institute for Biological Studies US United States (USA) (US) Nationwide Children's Hospital US United States (USA) (US) European Molecular Biology Laboratory (EMBL), Monterotondo IT Italy (IT)

How to cite

APA:

Toda, T., Bedrosian, T.A., Schafer, S.T., Cuoco, M.S., Linker, S.B., Ghassemzadeh, S.,... Gage, F.H. (2024). Long interspersed nuclear elements safeguard neural progenitors from precocious differentiation. Cell Reports, 43(2). https://doi.org/10.1016/j.celrep.2024.113774

MLA:

Toda, Tomohisa, et al. "Long interspersed nuclear elements safeguard neural progenitors from precocious differentiation." Cell Reports 43.2 (2024).

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