Micropillar substrates: A tool for studying cell mechanobiology

Gupta M, Kocgozlu L, Sarangi BR, Margadant F, Ashraf M, Ladoux B (2015)

Publication Type: Book chapter / Article in edited volumes

Publication year: 2015

Journal

Methods in Cell Biology Academic Press

Publisher: Academic Press Inc.

Series: Methods in Cell Biology

Book Volume: 125

Pages Range: 289-308

DOI: 10.1016/bs.mcb.2014.10.009

Abstract

Increasing evidence has shown that mechanical cues from the environment play an important role in cell biology. Mechanotransduction or the study of how cells can sense these mechanical cues, and respond to them, is an active field of research. However, it is still not clear how cells sense and respond to mechanical cues. Thus, new tools are being rapidly developed to quantitatively study cell mechanobiology. Particularly, force measurement tools such as micropillar substrates have provided new insights into the underlying mechanisms of mechanosensing. In this chapter, we provide detailed protocol for fabrication, characterization, functionalization, and use of the micropillar substrates.

Authors with CRIS profile

Benoit Ladoux

Involved external institutions

National University of Singapore (NUS) SG Singapore (SG) Institut Jacques Monod (IJM) FR France (FR)

How to cite

APA:

Gupta, M., Kocgozlu, L., Sarangi, B.R., Margadant, F., Ashraf, M., & Ladoux, B. (2015). Micropillar substrates: A tool for studying cell mechanobiology. In (pp. 289-308). Academic Press Inc..

MLA:

Gupta, Mukund, et al. "Micropillar substrates: A tool for studying cell mechanobiology." Academic Press Inc., 2015. 289-308.

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