Celebrating Soft Matter's 10th Anniversary: Cell division: a source of active stress in cellular monolayers
Doostmohammadi A, Thampi SP, Saw TB, Lim CT, Ladoux B, Yeomans JM (2015)
Publication Type: Journal article
Publication year: 2015
Journal
Book Volume: 11
Pages Range: 7328-7336
Journal Issue: 37
DOI: 10.1039/c5sm01382h
Abstract
We introduce the notion of cell division-induced activity and show that the cell division generates extensile forces and drives dynamical patterns in cell assemblies. Extending the hydrodynamic models of lyotropic active nematics we describe turbulent-like velocity fields that are generated by the cell division in a confluent monolayer of cells. We show that the experimentally measured flow field of dividing Madin-Darby Canine Kidney (MDCK) cells is reproduced by our modeling approach. Division-induced activity acts together with intrinsic activity of the cells in extensile and contractile cell assemblies to change the flow and director patterns and the density of topological defects. Finally we model the evolution of the boundary of a cellular colony and compare the fingering instabilities induced by cell division to experimental observations on the expansion of MDCK cell cultures.
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APA:
Doostmohammadi, A., Thampi, S.P., Saw, T.B., Lim, C.T., Ladoux, B., & Yeomans, J.M. (2015). Celebrating Soft Matter's 10th Anniversary: Cell division: a source of active stress in cellular monolayers. Soft Matter, 11(37), 7328-7336. https://doi.org/10.1039/c5sm01382h
MLA:
Doostmohammadi, Amin, et al. "Celebrating Soft Matter's 10th Anniversary: Cell division: a source of active stress in cellular monolayers." Soft Matter 11.37 (2015): 7328-7336.
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