Front-Rear Polarization by Mechanical Cues: From Single Cells to Tissues
Ladoux B, Mège RM, Trepat X (2016)
Publication Type: Journal article, Review article
Publication year: 2016
Journal
Book Volume: 26
Pages Range: 420-433
Journal Issue: 6
DOI: 10.1016/j.tcb.2016.02.002
Abstract
Directed cell migration is a complex process that involves front-rear polarization, characterized by cell adhesion and cytoskeleton-based protrusion, retraction, and contraction of either a single cell or a cell collective. Single cell polarization depends on a variety of mechanochemical signals including external adhesive cues, substrate stiffness, and confinement. In cell ensembles, coordinated polarization of migrating tissues results not only from the application of traction forces on the extracellular matrix but also from the transmission of mechanical stress through intercellular junctions. We focus here on the impact of mechanical cues on the establishment and maintenance of front-rear polarization from single cell to collective cell behaviors through local or large-scale mechanisms.
Authors with CRIS profile
Involved external institutions
Institut Jacques Monod (IJM)
France (FR)
Instituto de Bioingeniería de Cataluña / Institute for Bioengineering of Catalonia
Spain (ES)
France (FR)
Instituto de Bioingeniería de Cataluña / Institute for Bioengineering of Catalonia
Spain (ES)
How to cite
APA:
Ladoux, B., Mège, R.M., & Trepat, X. (2016). Front-Rear Polarization by Mechanical Cues: From Single Cells to Tissues. Trends in Cell Biology, 26(6), 420-433. https://doi.org/10.1016/j.tcb.2016.02.002
MLA:
Ladoux, Benoit, René Marc Mège, and Xavier Trepat. "Front-Rear Polarization by Mechanical Cues: From Single Cells to Tissues." Trends in Cell Biology 26.6 (2016): 420-433.
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